Gene Name	RPS6KA3
Gene ID	6197
Gene Full Name	ribosomal protein S6 kinase A3
Gene Alias	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|XLID19|p90-RSK2|pp90RSK2
Transcripts	ENSG00000177189
Virus	KSHV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Nucleoli, Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P51812
HGNC ID	HGNC:10432
OMIM ID	300075
Summary	This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	25320298	F66A	ORF45	ORF45	Cell line	R I T	View
2	30842327	F66A	ORF45	ORF45	Cell line	D I T	View

Data ID	Experiment type	Sample number	Platform
GSE232843	RNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE79029	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE202670	Chip-seq	14	Illumina Genome Analyzer (Homo sapiens)
GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
GSE158935	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE132777	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE147063	Chip-seq;GRO-seq;4C-seq	10	Illumina NextSeq 500 (Homo sapiens);Illumina Hiseq 2500 (Homo sapiens)
GSE207589	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens)
GSE241095	RNA-seq	44	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE135740	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
C   GSE52421	Chip-seq	18	Illumina Genome Analyzer IIx (Homo sapiens)
GSE280006	RNA-seq	14	NextSeq 550 (Homo sapiens)
C   GSE38411	Chip-seq	5	Illumina Genome Analyzer II (Homo sapiens);Illumina Genome Analyzer II (Human herpesvirus 8)
GSE260925	RNA-seq	24	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE56144	Chip-seq;RNA-seq	33	Illumina Genome Analyzer II (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE202670 - RPS6KA3 peak across samples

Peak Plot

> Dataset: GSE132777 - RPS6KA3 peak across samples

Peak Plot

> Dataset: GSE135740 - RPS6KA3 peak across samples

Peak Plot

> Dataset: GSE52421 - RPS6KA3 peak across samples

Peak Plot

> Dataset: GSE38411 - RPS6KA3 peak across samples

Peak Plot

> Dataset: GSE56144 - RPS6KA3 peak across samples

Peak Plot