Gene Name	TP63
Gene ID	8626
Gene Full Name	tumor protein p63
Gene Alias	AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L
Transcripts	ENSG00000073282
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;
Membrane Info	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q9H3D4
HGNC ID	HGNC:15979
OMIM ID	603273
Summary	This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5000193	chr3	189	204	315	708	View
5000197	chr3	514	153	40	707	View
5000405	chr3	210	14	2	226	View
5000766	chr3	84	0	4	88	View
5000889	chr3	29	18	25	72	View
5000900	chr3	29	17	24	70	View
5001371	chr3	7	29	1	37	View
5002680	chr3	9	0	0	9	View
5003228	chr3	4	0	0	4	View
5003229	chr3	4	0	0	4	View
5003883	chr3	2	0	0	2	View
5003884	chr3	1	1	0	2	View
5004715	chr3	0	0	0	0	View
5006448	chr3	8	0	0	8	View
5007251	chr3	22	15	8	45	View
5007252	chr3	15	95	17	127	View
5007253	chr3	12	2	0	14	View
5007254	chr3	13	3	3	19	View
5007255	chr3	3	0	0	3	View
5007351	chr3	2	2	0	4	View
5009814	chr3	0	0	0	0	View
5009815	chr3	41	195	12	248	View
5009816	chr3	10	3	0	13	View
5009817	chr3	0	0	0	0	View
5010127	chr3	166	24	1	191	View
5010138	chr3	2184	2480	1027	5691	View
5013471	chr3	26	21	1	48	View
5013472	chr3	530	137	181	848	View
5013473	chr3	62	36	2	100	View
5013474	chr3	63	35	1	99	View
5013475	chr3	211	108	5	324	View
5013476	chr3	77	218	15	310	View
5013477	chr3	77	218	15	310	View
5013478	chr3	7	0	0	7	View
5013479	chr3	7	0	0	7	View
5013480	chr3	7	0	0	7	View
5013481	chr3	7	0	0	7	View
5013482	chr3	5	0	0	5	View
5013483	chr3	11	1	0	12	View
5013484	chr3	0	0	0	0	View
5015879	chr3	71	72	65	208	View
5015880	chr3	68	57	26	151	View
5015881	chr3	63	45	18	126	View
5015882	chr3	33	55	0	88	View
5017562	chr3	19	2	2	23	View
5017563	chr3	34	1	1	36	View
5017565	chr3	0	0	0	0	View
5017566	chr3	0	0	0	0	View
5017567	chr3	7	3	6	16	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE40774	Expression array	134	Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE164690	scRNA-seq	51	Illumina NextSeq 500 (Homo sapiens)
GSE138080	Expression array	35	Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE197461	scRNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens)
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE183048 - TP63 peak across samples

Peak Plot

> Dataset: GSE143026 - TP63 peak across samples

Peak Plot