Gene Name	STAT3
Gene ID	6774
Gene Full Name	signal transducer and activator of transcription 3
Gene Alias	ADMIO|ADMIO1|APRF|HIES
Transcripts	ENSG00000168610
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID	P40763
HGNC ID	HGNC:11364
OMIM ID	102582
Summary	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	28767682	G7219C	LCR		Uterine Cervical Neoplasms	G R S L T	View
2	28767682	C7886G	LCR		Uterine Cervical Neoplasms	G R S L T	View
3	29630659	F4V	E6	E6		G T	View
4	29630659	L52A	E6	E6		G T	View

Data ID	Experiment type	Sample number	Platform
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
S   GSE197461	scRNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens)
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE199029	Variation;RNA-seq	44	NanoString Human nCounter PanCancer IO360 Panel
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
S   GSE226620	scRNA-seq	30	HiSeq X Ten (Homo sapiens)
GSE40774	Expression array	134	Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE139324	scRNA-seq	63	Illumina NextSeq 500 (Homo sapiens)
GSE138080	Expression array	35	Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE164690	scRNA-seq	51	Illumina NextSeq 500 (Homo sapiens)
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA

• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.

> Dataset: GSE197461 - Gene expression in cell subsets
> Dataset: GSE226620 - Gene expression in cell subsets