Gene Information
|
Gene Name
|
CACNB4 |
|
Gene ID
|
785
|
|
Gene Full Name
|
calcium voltage-gated channel auxiliary subunit beta 4 |
|
Gene Alias
|
CAB4|CACNLB4|EA5|EIG9|EJM|EJM4|EJM6 |
|
Transcripts
|
ENSG00000182389
|
|
Virus
|
EBV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
|
|
Membrane Info
|
Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
|
Uniport_ID
|
O00305
|
|
HGNC ID
|
HGNC:1404
|
|
OMIM ID
|
601949 |
|
Summary
|
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5. [provided by RefSeq, Aug 2016] |
Target gene [CACNB4] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 3000612 |
chr2 |
2 |
7 |
0 |
9 |
View |
Target gene [CACNB4] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE42867
|
Expression array |
12 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
C GSE246060
|
Chip-seq |
26 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE45919
|
Expression array |
24 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
GSE198332
|
Methylation profiling (Array) |
7 |
Infinium MethylationEPIC |
|
GSE223328
|
Expression array |
16 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
|
GSE208281
|
RNA-seq |
50 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE100458
|
Expression array |
14 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v21] |
|
C GSE198334
|
Chip-seq |
4 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE165194
|
RNA-seq |
3 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE246059
|
ATAC-seq |
8 |
Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE177046
|
RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE135644
|
Expression array |
10 |
Sentrix Human-6 v2 Expression BeadChip |
|
C GSE225248
|
Chip-seq |
12 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE102203
|
Expression array |
10 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [probe set (exon) version] |
|
GSE85599
|
Expression array |
17 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
GSE12452
|
Expression array |
41 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
GSE58240
|
Expression array |
32 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
GSE181906
|
RNA-seq |
24 |
Illumina NovaSeq 6000 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE246060 - CACNB4 peak across samples
|
Peak Plot
|
> Dataset: GSE198334 - CACNB4 peak across samples
|
Peak Plot
|
> Dataset: GSE246059 - CACNB4 peak across samples
|
Peak Plot
|
> Dataset: GSE225248 - CACNB4 peak across samples
|
Peak Plot
|
|
|
EBV Target gene Detail Information
