Virus Dataset Detail

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Dataset Information
Accession GSE223328
Status 2024/12/16
Title Plasma cell infiltration and tissue destruction are hallmarks of Epstein-Barr virus infection in periodontitis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Expression profiling by microarray was performed to delineate the EBV effect on the transcriptome of gingival tissues from periodontitis patients and healthy volunteers. The transcriptome analysis revealed numerous genes that were differentially expressed in periodontitis only when EBV was present. The most upregulated genes were related to inflammatory/immune response, B and plasma cell markers. Conversely, major downregulation was reported for genes related to epithelial tissue organization and structural support. The results provide new significant insights regarding EBV physiopathology in the gum, assigning a direct etiopathogenetic contribution to EBV in periodontitis.
Samples
GSM ID Sample info Characteristics Description
GSM6945706 P_EBV_d [257236337194_8] tissue:Periodontitis-affected gingiva; ebv status:EBV-positive; gender:Male; age:54y Gene expression in periodontitis-affected EBV-positive gingival tissue sample
GSM6945691 H_NEG_a [257236337192_7] tissue:Healthy gingiva; ebv status:EBV-negative; gender:Female; age:56y Gene expression in periodontally healthy EBV-negative gingival tissue sample
GSM6945692 H_NEG_b [257236337193_3] tissue:Healthy gingiva; ebv status:EBV-negative; gender:Male; age:19y Gene expression in periodontally healthy EBV-negative gingival tissue sample
GSM6945693 H_NEG_c [257236337194_2] tissue:Healthy gingiva; ebv status:EBV-negative; gender:Female; age:34y Gene expression in periodontally healthy EBV-negative gingival tissue sample
GSM6945694 H_NEG_d [257236337194_6] tissue:Healthy gingiva; ebv status:EBV-negative; gender:Female; age:25y Gene expression in periodontally healthy EBV-negative gingival tissue sample
GSM6945695 H_EBV_a [257236337192_1] tissue:Healthy gingiva; ebv status:EBV-positive; gender:Female; age:59y Gene expression in periodontally healthy EBV-positive gingival tissue sample
GSM6945696 H_EBV_b [257236337193_1] tissue:Healthy gingiva; ebv status:EBV-positive; gender:Female; age:45y Gene expression in periodontally healthy EBV-positive gingival tissue sample
GSM6945697 H_EBV_c [257236337193_6] tissue:Healthy gingiva; ebv status:EBV-positive; gender:Female; age:63y Gene expression in periodontally healthy EBV-positive gingival tissue sample
GSM6945698 H_EBV_d [257236337194_1] tissue:Healthy gingiva; ebv status:EBV-positive; gender:Female; age:45y Gene expression in periodontally healthy EBV-positive gingival tissue sample
GSM6945699 P_NEG_a [257236337192_3] tissue:Periodontitis-affected gingiva; ebv status:EBV-negative; gender:Male; age:38y Gene expression in periodontitis-affected EBV-negative gingival tissue sample
GSM6945700 P_NEG_b [257236337192_5] tissue:Periodontitis-affected gingiva; ebv status:EBV-negative; gender:Male; age:45y Gene expression in periodontitis-affected EBV-negative gingival tissue sample
GSM6945701 P_NEG_c [257236337193_4] tissue:Periodontitis-affected gingiva; ebv status:EBV-negative; gender:Male; age:56y Gene expression in periodontitis-affected EBV-negative gingival tissue sample
GSM6945702 P_NEG_d [257236337194_5] tissue:Periodontitis-affected gingiva; ebv status:EBV-negative; gender:Male; age:56y Gene expression in periodontitis-affected EBV-negative gingival tissue sample
GSM6945703 P_EBV_a [257236337192_8] tissue:Periodontitis-affected gingiva; ebv status:EBV-positive; gender:Female; age:71y Gene expression in periodontitis-affected EBV-positive gingival tissue sample
GSM6945704 P_EBV_b [257236337193_2] tissue:Periodontitis-affected gingiva; ebv status:EBV-positive; gender:Female; age:73y Gene expression in periodontitis-affected EBV-positive gingival tissue sample
GSM6945705 P_EBV_c [257236337194_3] tissue:Periodontitis-affected gingiva; ebv status:EBV-positive; gender:Male; age:46y Gene expression in periodontitis-affected EBV-positive gingival tissue sample
Platform GPL21185  : Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version]
Literature 39876607  
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* p<0.05 ** p<0.01