EBV Target gene Detail Information

> PDE3A Gene Search Result


Gene Information
Gene Name PDE3A
Gene ID 5139
Gene Full Name phosphodiesterase 3A
Gene Alias CGI-PDE|CGI-PDE A|CGI-PDE-A|HTNB
Transcripts ENSG00000172572
Virus EBV
Gene Type protein-coding
HPA Location Info Plasma membrane;
Membrane Info Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins
Uniport_ID Q14432
HGNC ID HGNC:8778
OMIM ID 123805
Summary This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Target gene [PDE3A] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
3001124 chr12 196 97 9 302 View

Target gene [PDE3A] related to Omics data
Data ID Experiment type Sample number Platform
GSE42867 Expression array 12 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
C
  GSE246060 		Chip-seq 26 Illumina NovaSeq 6000 (Homo sapiens)
E
  GSE45919 		Expression array 24 Illumina HumanHT-12 V4.0 expression beadchip
GSE198332 Methylation profiling (Array) 7 Infinium MethylationEPIC
GSE223328 Expression array 16 Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version]
GSE208281 RNA-seq 50 Illumina NextSeq 500 (Homo sapiens)
GSE100458 Expression array 14 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v21]
C
  GSE198334 		Chip-seq 4 Illumina NextSeq 500 (Homo sapiens)
GSE165194 RNA-seq 3 Illumina NextSeq 500 (Homo sapiens)
C
  GSE246059 		ATAC-seq 8 Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE177046 RNA-seq 6 Illumina HiSeq 2000 (Homo sapiens)
GSE135644 Expression array 10 Sentrix Human-6 v2 Expression BeadChip
C
  GSE225248 		Chip-seq 12 Illumina NextSeq 500 (Homo sapiens)
GSE102203 Expression array 10 [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [probe set (exon) version]
GSE85599 Expression array 17 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE12452 Expression array 41 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GSE58240 Expression array 32 Illumina HumanHT-12 V4.0 expression beadchip
GSE181906 RNA-seq 24 Illumina NovaSeq 6000 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE45919 - PDE3A expression across samples

Volcano Plot

Bar Plot