HIV Target gene Detail Information

> MDC1 Gene Search Result


Gene Information
Gene Name MDC1
Gene ID 9656
Gene Full Name mediator of DNA damage checkpoint 1
Gene Alias NFBD1
Transcripts ENSG00000137337
Virus HIV
Gene Type protein-coding
HPA Location Info Nucleoplasm, Nuclear bodies;
Membrane Info Cancer-related genes, Predicted intracellular proteins
Uniport_ID Q14676
HGNC ID HGNC:21163
OMIM ID 607593
Summary The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Target gene [MDC1] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000896 chr6 186 54 13 253 View
4000952 chr6 186 44 10 240 View
4000957 chr6 186 43 10 239 View
4000973 chr6 186 40 10 236 View
4000993 chr6 185 39 7 231 View
4000996 chr6 185 39 6 230 View
4000997 chr6 185 39 6 230 View
4000998 chr6 185 39 6 230 View
4000999 chr6 185 39 6 230 View
4001000 chr6 185 39 6 230 View
4001001 chr6 185 39 6 230 View
4001002 chr6 185 39 6 230 View
4001003 chr6 185 39 6 230 View
4001006 chr6 184 39 6 229 View
4001017 chr6 183 39 6 228 View
4001018 chr6 183 39 6 228 View
4001019 chr6 183 39 6 228 View
4001020 chr6 183 39 6 228 View
4001021 chr6 183 39 6 228 View
4001022 chr6 183 39 6 228 View
4001023 chr6 183 39 6 228 View
4001024 chr6 183 39 6 228 View
4001025 chr6 183 39 6 228 View
4001030 chr6 182 39 6 227 View
4001031 chr6 182 39 6 227 View
4001032 chr6 182 39 6 227 View
4001065 chr6 177 38 6 221 View
4001097 chr6 174 35 6 215 View
4001104 chr6 174 34 6 214 View
4001512 chr6 149 6 0 155 View
4002026 chr6 111 5 0 116 View
4002843 chr6 75 2 0 77 View
4003556 chr6 50 9 0 59 View

Target gene [MDC1] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE221688 		Chip-seq;scATAC-Seq;scRNA-Seq 12 Illumina NovaSeq 6000 (Homo sapiens)
GSE99737 RNA-seq 9 Illumina HiSeq 2500 (Homo sapiens)
GSE144332 RNA-seq 75 NextSeq 550 (Homo sapiens)
C
  GSE165705 		Chip-seq 30 Illumina NovaSeq 6000 (Homo sapiens)
GSE164264 RNA-seq 6 BGISEQ-500 (Homo sapiens)
GSE262621 RNA-seq 70 Illumina NovaSeq 6000 (Homo sapiens)
GSE128121 RNA-seq 16 Illumina HiSeq 4000 (Homo sapiens)
GSE162914 RNA-seq 211 Illumina HiSeq 2500 (Homo sapiens)
GSE279982 Methylation profiling (Array) 576 Infinium MethylationEPIC
C
  GSE144329 		ATAC-seq 96 NextSeq 550 (Homo sapiens)
GSE205204 RNA-seq 14 Illumina NovaSeq 6000 (Homo sapiens)
GSE125686 RNA-seq 62 Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339 scRNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE220859 		Chip-seq 11 Illumina NovaSeq 6000 (Homo sapiens)
GSE165708 RNA-seq 100 Illumina HiSeq 4000 (Homo sapiens)
C
  GSE211651 		Chip-seq;RNA-seq;PRO-seq 39 Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE100376 		ATAC-seq 24 Illumina NextSeq 500 (Homo sapiens)
GSE167211 RNA-seq 1 Illumina HiSeq 2000 (Homo sapiens)
C
  GSE100266 		ATAC-seq;Chip-seq;RNA-seq 32 Illumina HiSeq 2500 (Homo sapiens)
C
  GSE165703 		ATAC-seq 82 Illumina HiSeq 4000 (Homo sapiens)
GSE246082 RNA-seq 6 Illumina HiSeq 4000 (Homo sapiens)


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE221688 - MDC1 peak across samples

Peak Plot

> Dataset: GSE165705 - MDC1 peak across samples

Peak Plot

> Dataset: GSE144329 - MDC1 peak across samples

Peak Plot

> Dataset: GSE220859 - MDC1 peak across samples

Peak Plot

> Dataset: GSE211651 - MDC1 peak across samples

Peak Plot

> Dataset: GSE100376 - MDC1 peak across samples

Peak Plot

> Dataset: GSE100266 - MDC1 peak across samples

Peak Plot

> Dataset: GSE165703 - MDC1 peak across samples

Peak Plot