Gene Name	NFKB1
Gene ID	4790
Gene Full Name	nuclear factor kappa B subunit 1
Gene Alias	CVID12|EBP-1|KBF1|NF-kB|NF-kB1|NF-kappa-B1|NF-kappaB|NF-kappabeta|NFKB-p105|NFKB-p50|NFkappaB
Transcripts	ENSG00000109320
Virus	EBV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors
Uniport_ID	P19838
HGNC ID	HGNC:7794
OMIM ID	164011
Summary	This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	19119421	K122A	BILF1	BILF1	Cell line	T	View
2	9123876	Z214R	BZLF1	BZLF1	Cell line	T	View
3	9123876	Z214S	BZLF1	BZLF1	Cell line	T	View
4	9123876	Z218R	BZLF1	BZLF1	Cell line	T	View
5	9123876	Z218S	BZLF1	BZLF1	Cell line	T	View
6	9123876	Z225E	BZLF1	BZLF1	Cell line	T	View
7	9123876	Y200E	BZLF1	BZLF1	Cell line	T	View
8	9733827	Q206A	LMP-1	LMP-1	Cell line	T	View
9	9733827	P204A	LMP-1	LMP-1	Cell line	T	View
10	22384168	D150A	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
11	22384168	M129I	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
12	22384168	D46N	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
13	22384168	E328A	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
14	22384168	F106Y	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
15	22384168	F144I	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
16	22384168	L151I	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
17	22384168	I124V	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
18	22384168	I137L	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
19	22384168	I144F	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
20	22384168	I152L	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
21	22384168	I68L	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
22	22384168	I85L	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
23	22384168	L150I	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
24	22384168	L178M	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
25	22384168	L29V	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
26	22384168	Q189P	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
27	22384168	S192T	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
28	22384168	V43L	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
29	22384168	G212S	LMP-1	LMP-1	Lymphoproliferative Disorders	L T	View
30	21560118	D150A	LMP-1	LMP-1		T	View
31	14687985	69bp del	LMP-1	LMP-1	B-Cell Lymphocytosis	T	View

Data ID	Experiment type	Sample number	Platform
GSE42867	Expression array	12	[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
C   GSE246060	Chip-seq	26	Illumina NovaSeq 6000 (Homo sapiens)
E   GSE45919	Expression array	24	Illumina HumanHT-12 V4.0 expression beadchip
GSE198332	Methylation profiling (Array)	7	Infinium MethylationEPIC
GSE223328	Expression array	16	Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version]
GSE208281	RNA-seq	50	Illumina NextSeq 500 (Homo sapiens)
GSE100458	Expression array	14	[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v21]
C   GSE198334	Chip-seq	4	Illumina NextSeq 500 (Homo sapiens)
GSE165194	RNA-seq	3	Illumina NextSeq 500 (Homo sapiens)
C   GSE246059	ATAC-seq	8	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE177046	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
GSE135644	Expression array	10	Sentrix Human-6 v2 Expression BeadChip
C   GSE225248	Chip-seq	12	Illumina NextSeq 500 (Homo sapiens)
GSE102203	Expression array	10	[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [probe set (exon) version]
GSE85599	Expression array	17	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE12452	Expression array	41	[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GSE58240	Expression array	32	Illumina HumanHT-12 V4.0 expression beadchip
GSE181906	RNA-seq	24	Illumina NovaSeq 6000 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE45919 - NFKB1 expression across samples

Volcano Plot

Bar Plot