Gene Name	CCL2
Gene ID	6347
Gene Full Name	C-C motif chemokine ligand 2
Gene Alias	GDCF-2|HC11|HSMCR30|MCAF|MCP-1|MCP1|SCYA2|SMC-CF
Transcripts	ENSG00000108691
Virus	HCMV
Gene Type	protein-coding
HPA Location Info	Golgi apparatus;Vesicles;Secreted to blood;
Membrane Info	Cancer-related genes, Candidate cardiovascular disease genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P13500
HGNC ID	HGNC:10618
OMIM ID	158105
Summary	This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	34704798	A19D	US28	US28	Cytomegalovirus infections	R L T	View

Data ID	Experiment type	Sample number	Platform
GSE152114	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
GSE163707	RNA-seq	96	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (blank sample)
GSE168598	RNA-seq	154	Illumina HiSeq 3000 (Homo sapiens)
GSE248772	RNA-seq	84	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE164861	Chip-seq;RNA-seq;ATAC-seq	79	Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5);Illumina HiSeq 4000 (Human betaherpesvirus 5);Illumina NovaSeq 6000 (Human betaherpesvirus 5);Illumina HiSeq 4000 (Homo sapiens; Human betaherpesvirus 5)
GSE182788	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
C   GSE53271	Chip-seq	2	Illumina HiSeq 2000 (Homo sapiens)
C   GSE185618	Chip-seq	25	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE193759	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2000 (Homo sapiens; Human betaherpesvirus 5)
GSE94724	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
GSE254735	RNA-seq	4	Illumina NovaSeq 6000 (Homo sapiens)
GSE136217	RNA-seq	7	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
GSE73853	RNA-seq	13	Illumina HiSeq 2000 (Homo sapiens)
GSE217832	RNA-seq	8	Illumina NextSeq 500 (Homo sapiens)
GSE164843	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C   GSE254741	ATAC-seq;ChIP-seq;HiChIP;RNA-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164839	RNA-seq	4	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C   GSE171518	Chip-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Human betaherpesvirus 5)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE164861 - CCL2 peak across samples

Peak Plot

> Dataset: GSE53271 - CCL2 peak across samples

Peak Plot

> Dataset: GSE185618 - CCL2 peak across samples

Peak Plot

> Dataset: GSE254741 - CCL2 peak across samples

Peak Plot

> Dataset: GSE171518 - CCL2 peak across samples

Peak Plot