Accession	GSE53271
Status	2015/3/18
Title	Release of Human Cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
Organism	Homo sapiens
Experiment type	Genome binding/occupancy profiling by high throughput sequencing
Summary	A new actor of HCMV latency is unveiled, where KAP1 protein binds to viral genome to recruit SetDB1 and trigger H3K9 trimethylation. A switch of phosphorylation state mediated by mTOR leads to lytic replication, opening new approaches to curtail CMV infection but also to purge the virus from organ transplants.
Samples	GSM ID Sample info Characteristics Description GSM1288792 ChIP-seq:KAP1 cell type:Human hematopoietic stem cells CD34+ freshly purified; disease state:5 days of HCMV infection; sample pool:mixed patients; antibody:against KAP1 - GSM1288793 CHIP-seq:Ti cell type:Human hematopoietic stem cells CD34+ freshly purified; disease state:5 days of HCMV infection; sample pool:mixed patients; antibody:none -
Platform	GPL11154  : Illumina HiSeq 2000 (Homo sapiens)
Literature	25846574
Download	Download Genome Binding/Occupancy Profiling Analysis Data