Virus Dataset Detail

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Dataset Information
Accession GSE193759
Status 2022/3/1
Title Downregulation of Neurodevelopmental Gene Expression in iPSC-Derived Cerebral Organoids Upon Infection by Human Cytomegalovirus
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We report the application of bulk RNA sequencing on cerebral organoids infected with HCMV TB40eGFP virus or uninfected, within the infected groups the organoids were sorted into 3 distinct populations prior to sequencing based on GFP expression as a proxy for level of infection. These populations have been denoted GFP (+), GFP Inter, GFP (-), for each sorted population 3 organoids of the same line and from the same differentiation were combined to ensure sufficient cell numbers for bulk sequencing analysis.
Samples
GSM ID Sample info Characteristics Description
GSM5820568 iPSC derived cerebral organoid - Mock A cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:Uninfected MockA
GSM5820569 iPSC derived cerebral organoid - Mock C cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:Uninfected MockC
GSM5820570 iPSC derived cerebral organoid - Mock D cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:Uninfected MockD
GSM5820571 iPSC derived cerebral organoid - Mock M3_D30 cell type:iPSC derived cerebral organoid; line:WT 21.8; treatment:Uninfected M3
GSM5820572 iPSC derived cerebral organoid - Pos 1 cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:HCMV TB40eGFP Infected GFP_Pos_1
GSM5820573 iPSC derived cerebral organoid - Pos 2 cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:HCMV TB40eGFP Infected GFP_Pos_2
GSM5820574 iPSC derived cerebral organoid - Inter 1 cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:HCMV TB40eGFP Infected GFP_Inter_1
GSM5820575 iPSC derived cerebral organoid - Inter 2 cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:HCMV TB40eGFP Infected GFP_Inter_2
GSM5820576 iPSC derived cerebral organoid - Inter 3 cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:HCMV TB40eGFP Infected GFP_Inter_3
GSM5820577 iPSC derived cerebral organoid - Neg 1 cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:HCMV TB40eGFP Infected GFP_Neg_1
GSM5820578 iPSC derived cerebral organoid - Neg 2 cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:HCMV TB40eGFP Infected GFP_Neg_2
GSM5820579 iPSC derived cerebral organoid - Neg 3 cell type:iPSC derived cerebral organoid; line:WT 4.2; treatment:HCMV TB40eGFP Infected GFP_Neg_3
Platform GPL11154  GPL24259  : Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2000 (Homo sapiens; Human betaherpesvirus 5)
Literature 35391828  
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xCell Plot
* p<0.05 ** p<0.01