Gene Name	CCL5
Gene ID	6352
Gene Full Name	C-C motif chemokine ligand 5
Gene Alias	D17S136E|RANTES|SCYA5|SIS-delta|SISd|TCP228|eoCP
Transcripts	ENSG00000271503
Virus	HCMV
Gene Type	protein-coding
HPA Location Info	Secreted to blood;
Membrane Info	Cancer-related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	P13501
HGNC ID	HGNC:10632
OMIM ID	187011
Summary	This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	34704798	A19D	US28	US28	Cytomegalovirus infections	R L T	View

Data ID	Experiment type	Sample number	Platform
GSE152114	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
GSE136217	RNA-seq	7	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C   GSE164861	Chip-seq;RNA-seq;ATAC-seq	79	Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5);Illumina HiSeq 4000 (Human betaherpesvirus 5);Illumina NovaSeq 6000 (Human betaherpesvirus 5);Illumina HiSeq 4000 (Homo sapiens; Human betaherpesvirus 5)
GSE73853	RNA-seq	13	Illumina HiSeq 2000 (Homo sapiens)
E   GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
E   GSE163707	RNA-seq	96	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (blank sample)
GSE217832	RNA-seq	8	Illumina NextSeq 500 (Homo sapiens)
GSE168598	RNA-seq	154	Illumina HiSeq 3000 (Homo sapiens)
E   GSE182788	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
C   GSE53271	Chip-seq	2	Illumina HiSeq 2000 (Homo sapiens)
GSE164843	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
E   GSE164839	RNA-seq	4	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C   GSE254741	ATAC-seq;ChIP-seq;HiChIP;RNA-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE185618	Chip-seq	25	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE171518	Chip-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Human betaherpesvirus 5)
GSE248772	RNA-seq	84	Illumina NovaSeq 6000 (Homo sapiens)
GSE193759	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2000 (Homo sapiens; Human betaherpesvirus 5)
GSE94724	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE280380 - CCL5 expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE163707 - CCL5 expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE182788 - CCL5 expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE164839 - CCL5 expression across samples

Volcano Plot

Bar Plot