Gene Name	CD4
Gene ID	920
Gene Full Name	CD4 molecule
Gene Alias	CD4mut|IMD79|Leu-3|OKT4D|T4
Transcripts	ENSG00000010610
Virus	HCMV
Gene Type	protein-coding
HPA Location Info	Plasma membrane;
Membrane Info	CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P01730
HGNC ID	HGNC:1678
OMIM ID	186940
Summary	This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	14739146	A594V	UL97	UL97	Cytomegalovirus infections	D I C T	View
2	14739146	H520Q	UL97	UL97	Cytomegalovirus infections	D I C T	View
3	14739146	P522S	UL54	UL54	Cytomegalovirus infections	D I C T	View

Data ID	Experiment type	Sample number	Platform
GSE152114	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
GSE163707	RNA-seq	96	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (blank sample)
GSE168598	RNA-seq	154	Illumina HiSeq 3000 (Homo sapiens)
GSE248772	RNA-seq	84	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE164861	Chip-seq;RNA-seq;ATAC-seq	79	Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5);Illumina HiSeq 4000 (Human betaherpesvirus 5);Illumina NovaSeq 6000 (Human betaherpesvirus 5);Illumina HiSeq 4000 (Homo sapiens; Human betaherpesvirus 5)
GSE182788	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
C   GSE53271	Chip-seq	2	Illumina HiSeq 2000 (Homo sapiens)
C   GSE185618	Chip-seq	25	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE193759	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2000 (Homo sapiens; Human betaherpesvirus 5)
GSE94724	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
GSE254735	RNA-seq	4	Illumina NovaSeq 6000 (Homo sapiens)
GSE136217	RNA-seq	7	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
GSE73853	RNA-seq	13	Illumina HiSeq 2000 (Homo sapiens)
GSE217832	RNA-seq	8	Illumina NextSeq 500 (Homo sapiens)
GSE164843	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C   GSE254741	ATAC-seq;ChIP-seq;HiChIP;RNA-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164839	RNA-seq	4	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C   GSE171518	Chip-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Human betaherpesvirus 5)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE164861 - CD4 peak across samples

Peak Plot

> Dataset: GSE53271 - CD4 peak across samples

Peak Plot

> Dataset: GSE185618 - CD4 peak across samples

Peak Plot

> Dataset: GSE254741 - CD4 peak across samples

Peak Plot

> Dataset: GSE171518 - CD4 peak across samples

Peak Plot