HCMV Target gene Detail Information

> MLKL Gene Search Result


Gene Information
Gene Name MLKL
Gene ID 197259
Gene Full Name mixed lineage kinase domain like pseudokinase
Gene Alias hMLKL
Transcripts ENSG00000168404
Virus HCMV
Gene Type protein-coding
HPA Location Info Plasma membrane;Cell Junctions, Cytosol;
Membrane Info Enzymes, Predicted intracellular proteins, Transporters
Uniport_ID Q8NB16
HGNC ID HGNC:26617
OMIM ID 615153
Summary This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Target gene [MLKL] related to virus gene/protein/region

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section


ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 32690704 C131R
UL36
UL36
Cell line
T
 View

Target gene [MLKL] related to Omics data
Data ID Experiment type Sample number Platform
GSE152114 RNA-seq 4 Illumina HiSeq 2000 (Homo sapiens)
GSE280380 RNA-seq 54 Illumina NovaSeq 6000 (Homo sapiens)
GSE163707 RNA-seq 96 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (blank sample)
GSE168598 RNA-seq 154 Illumina HiSeq 3000 (Homo sapiens)
GSE248772 RNA-seq 84 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE164861 		Chip-seq;RNA-seq;ATAC-seq 79 Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5);Illumina HiSeq 4000 (Human betaherpesvirus 5);Illumina NovaSeq 6000 (Human betaherpesvirus 5);Illumina HiSeq 4000 (Homo sapiens; Human betaherpesvirus 5)
GSE182788 RNA-seq 4 Illumina HiSeq 2000 (Homo sapiens)
C
  GSE53271 		Chip-seq 2 Illumina HiSeq 2000 (Homo sapiens)
C
  GSE185618 		Chip-seq 25 Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE193759 RNA-seq 12 Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2000 (Homo sapiens; Human betaherpesvirus 5)
GSE94724 RNA-seq 4 Illumina HiSeq 2000 (Homo sapiens)
GSE254735 RNA-seq 4 Illumina NovaSeq 6000 (Homo sapiens)
GSE136217 RNA-seq 7 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
GSE73853 RNA-seq 13 Illumina HiSeq 2000 (Homo sapiens)
GSE217832 RNA-seq 8 Illumina NextSeq 500 (Homo sapiens)
GSE164843 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C
  GSE254741 		ATAC-seq;ChIP-seq;HiChIP;RNA-seq 30 Illumina NovaSeq 6000 (Homo sapiens)
GSE164839 RNA-seq 4 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C
  GSE171518 		Chip-seq 16 Illumina NovaSeq 6000 (Homo sapiens; Human betaherpesvirus 5)


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE164861 - MLKL peak across samples

Peak Plot

> Dataset: GSE53271 - MLKL peak across samples

Peak Plot

> Dataset: GSE185618 - MLKL peak across samples

Peak Plot

> Dataset: GSE254741 - MLKL peak across samples

Peak Plot

> Dataset: GSE171518 - MLKL peak across samples

Peak Plot