HCMV Target gene Detail Information

> PDGFRA Gene Search Result


Gene Information
Gene Name PDGFRA
Gene ID 5156
Gene Full Name platelet derived growth factor receptor alpha
Gene Alias CD140A|PDGFR-2|PDGFR2
Transcripts ENSG00000134853
Virus HCMV
Gene Type protein-coding
HPA Location Info Nucleoplasm, Plasma membrane;Nuclear bodies, Cell Junctions, Primary cilium;Intracellular and membrane;
Membrane Info Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Uniport_ID P16234
HGNC ID HGNC:8803
OMIM ID 173490
Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Target gene [PDGFRA] related to virus gene/protein/region

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section


ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 34201364 D84Y
gN
UL73
Cell line
R
S
T
 View
2 34201364 H177N
gB
UL55
Cell line
R
S
T
 View
3 34201364 I417V
gH
UL75
Cell line
R
S
T
 View
4 34201364 L47P
gO
UL74
Cell line
R
S
T
 View
5 34201364 S48Y
gO
UL74
Cell line
R
S
T
 View

Target gene [PDGFRA] related to Omics data
Data ID Experiment type Sample number Platform
GSE152114 RNA-seq 4 Illumina HiSeq 2000 (Homo sapiens)
E
  GSE280380 		RNA-seq 54 Illumina NovaSeq 6000 (Homo sapiens)
GSE163707 RNA-seq 96 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (blank sample)
GSE168598 RNA-seq 154 Illumina HiSeq 3000 (Homo sapiens)
GSE248772 RNA-seq 84 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE164861 		Chip-seq;RNA-seq;ATAC-seq 79 Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5);Illumina HiSeq 4000 (Human betaherpesvirus 5);Illumina NovaSeq 6000 (Human betaherpesvirus 5);Illumina HiSeq 4000 (Homo sapiens; Human betaherpesvirus 5)
GSE182788 RNA-seq 4 Illumina HiSeq 2000 (Homo sapiens)
C
  GSE53271 		Chip-seq 2 Illumina HiSeq 2000 (Homo sapiens)
C
  GSE185618 		Chip-seq 25 Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE193759 RNA-seq 12 Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2000 (Homo sapiens; Human betaherpesvirus 5)
GSE94724 RNA-seq 4 Illumina HiSeq 2000 (Homo sapiens)
GSE254735 RNA-seq 4 Illumina NovaSeq 6000 (Homo sapiens)
GSE136217 RNA-seq 7 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
GSE73853 RNA-seq 13 Illumina HiSeq 2000 (Homo sapiens)
E
  GSE217832 		RNA-seq 8 Illumina NextSeq 500 (Homo sapiens)
GSE164843 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C
  GSE254741 		ATAC-seq;ChIP-seq;HiChIP;RNA-seq 30 Illumina NovaSeq 6000 (Homo sapiens)
GSE164839 RNA-seq 4 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C
  GSE171518 		Chip-seq 16 Illumina NovaSeq 6000 (Homo sapiens; Human betaherpesvirus 5)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE280380 - PDGFRA expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE217832 - PDGFRA expression across samples

Volcano Plot

Bar Plot