Virus Dataset Detail

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Dataset Information
Accession GSE124802
Status 2020/1/1
Title The epigenetic landscapes of histone modifications on HSV-1 genome in human THP-1 cells [RNA-seq]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To study the dynamic changes of histone modifications across HSV-1 genome during lytic infection in THP-1 cells. Totally 20 maps of HSV-1 epigenome were generated at 5 different time points after infection, together with their corresponding gene expression profiles.We found that histone modifications were detected on HSV-1 genome soon after infection; all four studied modifications, H3K9me3, H3K27me3, H3K4me3 and H3K27ac, change rapidly along with virus life cycle progression.The transcription repression marks, H3K9me3 and H3K27me3, tended to decrease along with infection process, and the transcription activation mark H3K27ac increased on viral genome, which were aligned with increased expression of viral genes. Moreover, treatment with C646, an inhibitor for H3K27ac transferase p300, inhibited expression of viral genes; and EPZ6438, an inhibitor for H3K27 methyltransferase EZH2, enhanced viral gene expression.
Samples
GSM ID Sample info Characteristics Description
GSM3554281 HSV-1_2H_RNASeq_rep2 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 2h HSV-RNA-2h.bw;HSV-RNA-2h-count.txt
GSM3554282 HSV-1_4H_RNASeq_rep1 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 4h HSV-RNA-4h.bw;HSV-RNA-4h-count.txt
GSM3554283 HSV-1_4H_RNASeq_rep2 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 4h HSV-RNA-4h.bw;HSV-RNA-4h-count.txt
GSM3554284 HSV-1_8H_RNASeq_rep1 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 8h HSV-RNA-8h.bw;HSV-RNA-8h-count.txt
GSM3554285 HSV-1_8H_RNASeq_rep2 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 8h HSV-RNA-8h.bw;HSV-RNA-8h-count.txt
GSM3554286 HSV-1_24H_RNASeq_rep1 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 24h HSV-RNA-24h.bw;HSV-RNA-24h-count.txt
GSM3554287 HSV-1_24H_RNASeq_rep2 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 24h HSV-RNA-24h.bw;HSV-RNA-24h-count.txt
GSM3554288 HSV-1_DMSO_RNASeq_rep1 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 4h + DMSO 4h HSV-RNA-DMSO.bw
GSM3554289 HSV-1_DMSO_RNASeq_rep2 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 4h + DMSO 4h HSV-RNA-DMSO.bw
GSM3554290 HSV-1_C646_RNAseq_rep1 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 4h + C646 4h HSV-RNA-C646.bw
GSM3554291 HSV-1_C646_RNAseq_rep2 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 4h + C646 4h HSV-RNA-C646.bw
GSM3554292 HSV-1_EPZ6438_RNAseq_rep1 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 4h + EPZ6438 4h HSV-RNA-EPZ6438.bw
GSM3554293 HSV-1_EPZ6438_RNAseq_rep2 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 4h + EPZ6438 4h HSV-RNA-EPZ6438.bw
GSM3554278 HSV-1_1H_RNASeq_rep1 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 1h HSV-RNA-1h.bw;HSV-RNA-1h-count.txt
GSM3554279 HSV-1_1H_RNASeq_rep2 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 1h HSV-RNA-1h.bw;HSV-RNA-1h-count.txt
GSM3554280 HSV-1_2H_RNASeq_rep1 host cell line:THP-1; host cell type:monocyte; tissue:peripheral blood; disease:acute monocytic leukemia; treatment:HSV-1 infect 2h HSV-RNA-2h.bw;HSV-RNA-2h-count.txt
Platform GPL26016  : HiSeq X Ten (Homo sapiens; Human alphaherpesvirus 1)
Literature 32014498  
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xCell Plot
* p<0.05 ** p<0.01