Virus Dataset Detail

> Detail information for each sample

Dataset Information
Accession GSE165132
Status 2021/4/20
Title HIV-exposed seronegative sex workers express high levels of regulatory T cells, low levels of T cell activation and an intact ectocervical tissue microenvironment
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Immunological correlates of natural resistance to HIV have been identified in HIV-exposed seronegative (HESN) individuals. The cervicovaginal epithelium has not been studied for such correlates despite constituting an important barrier against sexual HIV transmission. To fill this gap in knowledge, we collected samples of blood and genital mucosa from Kenyan HESN sex workers (n=29) and controls (n=33). The samples were analyzed by several methods including tissue-based RNA sequencing. A significantly higher relative proportion of regulatory T cells and lower proportion of activated cervical T cells were found in the HESN group compared with the controls. However, they had comparable tissue RNA transcriptional profiles. In conclusion, the identification of an increased proportion of regulatory T cells in blood, a lower proportion of activated cervical T cells, and an intact ectocervical microenvironment in HESN individuals add new data to current knowledge about natural resistance to sexual transmission of HIV.
Samples
GSM ID Sample info Characteristics Description
GSM5026802 NN_28 group:NN; subjectid:P066; Sex:female; tissue:Ectocervix -
GSM5026803 NN_29 group:NN; subjectid:P081; Sex:female; tissue:Ectocervix -
GSM5026804 NN_30 group:NN; subjectid:P079; Sex:female; tissue:Ectocervix -
GSM5026805 NN_31 group:NN; subjectid:P070; Sex:female; tissue:Ectocervix -
GSM5026806 NN_32 group:NN; subjectid:P077; Sex:female; tissue:Ectocervix -
GSM5026807 NN_33 group:NN; subjectid:P083; Sex:female; tissue:Ectocervix -
GSM5026752 HESN_01 group:HESN; subjectid:P026; Sex:female; tissue:Ectocervix -
GSM5026753 HESN_02 group:HESN; subjectid:P020; Sex:female; tissue:Ectocervix -
GSM5026754 HESN_03 group:HESN; subjectid:P004; Sex:female; tissue:Ectocervix -
GSM5026755 HESN_04 group:HESN; subjectid:P002; Sex:female; tissue:Ectocervix -
GSM5026756 HESN_05 group:HESN; subjectid:P048; Sex:female; tissue:Ectocervix -
GSM5026757 HESN_06 group:HESN; subjectid:P053; Sex:female; tissue:Ectocervix -
GSM5026758 HESN_07 group:HESN; subjectid:P044; Sex:female; tissue:Ectocervix -
GSM5026759 HESN_08 group:HESN; subjectid:P065; Sex:female; tissue:Ectocervix -
GSM5026760 HESN_09 group:HESN; subjectid:P024; Sex:female; tissue:Ectocervix -
GSM5026761 HESN_10 group:HESN; subjectid:P043; Sex:female; tissue:Ectocervix -
GSM5026762 HESN_11 group:HESN; subjectid:P008; Sex:female; tissue:Ectocervix -
GSM5026763 HESN_12 group:HESN; subjectid:P006; Sex:female; tissue:Ectocervix -
GSM5026764 HESN_13 group:HESN; subjectid:P059; Sex:female; tissue:Ectocervix -
GSM5026765 HESN_14 group:HESN; subjectid:P014; Sex:female; tissue:Ectocervix -
GSM5026766 HESN_15 group:HESN; subjectid:P029; Sex:female; tissue:Ectocervix -
GSM5026767 HESN_17 group:HESN; subjectid:P005; Sex:female; tissue:Ectocervix -
GSM5026768 HESN_18 group:HESN; subjectid:P001; Sex:female; tissue:Ectocervix -
GSM5026769 HESN_19 group:HESN; subjectid:P033; Sex:female; tissue:Ectocervix -
GSM5026770 HESN_20 group:HESN; subjectid:P022; Sex:female; tissue:Ectocervix -
GSM5026771 HESN_21 group:HESN; subjectid:P034; Sex:female; tissue:Ectocervix -
GSM5026772 HESN_22 group:HESN; subjectid:P021; Sex:female; tissue:Ectocervix -
GSM5026773 HESN_23 group:HESN; subjectid:P003; Sex:female; tissue:Ectocervix -
GSM5026774 HESN_24 group:HESN; subjectid:P039; Sex:female; tissue:Ectocervix -
GSM5026775 HESN_25 group:HESN; subjectid:P036; Sex:female; tissue:Ectocervix -
GSM5026776 HESN_26 group:HESN; subjectid:P041; Sex:female; tissue:Ectocervix -
GSM5026777 HESN_27 group:HESN; subjectid:P025; Sex:female; tissue:Ectocervix -
GSM5026778 HESN_28 group:HESN; subjectid:P017; Sex:female; tissue:Ectocervix -
GSM5026779 HESN_29 group:HESN; subjectid:P019; Sex:female; tissue:Ectocervix -
GSM5026780 NN_01 group:NN; subjectid:P057; Sex:female; tissue:Ectocervix -
GSM5026781 NN_02 group:NN; subjectid:P068; Sex:female; tissue:Ectocervix -
GSM5026782 NN_03 group:NN; subjectid:P050; Sex:female; tissue:Ectocervix -
GSM5026783 NN_04 group:NN; subjectid:P080; Sex:female; tissue:Ectocervix -
GSM5026784 NN_06 group:NN; subjectid:P073; Sex:female; tissue:Ectocervix -
GSM5026785 NN_07 group:NN; subjectid:P072; Sex:female; tissue:Ectocervix -
GSM5026786 NN_08 group:NN; subjectid:P071; Sex:female; tissue:Ectocervix -
GSM5026787 NN_09 group:NN; subjectid:P031; Sex:female; tissue:Ectocervix -
GSM5026788 NN_11 group:NN; subjectid:P062; Sex:female; tissue:Ectocervix -
GSM5026789 NN_13 group:NN; subjectid:P075; Sex:female; tissue:Ectocervix -
GSM5026790 NN_14 group:NN; subjectid:P046; Sex:female; tissue:Ectocervix -
GSM5026791 NN_15 group:NN; subjectid:P064; Sex:female; tissue:Ectocervix -
GSM5026792 NN_16 group:NN; subjectid:P042; Sex:female; tissue:Ectocervix -
GSM5026793 NN_18 group:NN; subjectid:P086; Sex:female; tissue:Ectocervix -
GSM5026794 NN_19 group:NN; subjectid:P069; Sex:female; tissue:Ectocervix -
GSM5026795 NN_20 group:NN; subjectid:P027; Sex:female; tissue:Ectocervix -
GSM5026796 NN_21 group:NN; subjectid:P074; Sex:female; tissue:Ectocervix -
GSM5026797 NN_22 group:NN; subjectid:P045; Sex:female; tissue:Ectocervix -
GSM5026798 NN_23 group:NN; subjectid:P067; Sex:female; tissue:Ectocervix -
GSM5026799 NN_24 group:NN; subjectid:P082; Sex:female; tissue:Ectocervix -
GSM5026800 NN_26 group:NN; subjectid:P052; Sex:female; tissue:Ectocervix -
GSM5026801 NN_27 group:NN; subjectid:P078; Sex:female; tissue:Ectocervix -
Platform GPL21697  : NextSeq 550 (Homo sapiens)
Literature 33806390  
Download Download xCell Data  Download Expression Analysis Data  
xCell Plot
* p<0.05 ** p<0.01