Accession	GSE185234
Status	2023/6/20
Title	The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes (ATAC-seq I)
Organism	Homo sapiens
Experiment type	Genome binding/occupancy profiling by high throughput sequencing
Summary	We report that HSV-1 gives rise to transposase accessible chromatin in gene downstream areas, in regions that show transcription termination defects. We show that the viral protein ICP22 is responsible for this open chromatin.
Samples	GSM ID Sample info Characteristics Description GSM5608518 mock infection, replicate 1 infection status: N/A;virus strain: N/A followed ATACseq protocol GSM5608519 mock infection, replicate 2 infection status: N/A;virus strain: N/A followed ATACseq protocol GSM5608520 HSV-1 wt, strain 17, replicate 1 infection status: 8 hpi;virus strain: strain 17 followed ATACseq protocol GSM5608521 HSV-1 wt, strain 17, replicate 2 infection status: 8 hpi;virus strain: strain 17 followed ATACseq protocol GSM5608522 HSV-1 wt, strain 17, +PAA, replicate 1 infection status: 8 hpi;treatment: PAA 300ug/ml;virus strain: strain 17 followed ATACseq protocol GSM5608523 HSV-1 wt, strain 17, +PAA, replicate 2 infection status: 8 hpi;treatment: PAA 300ug/ml;virus strain: strain 17 followed ATACseq protocol GSM5608524 HSV-1 lacking expression of ICP0, replicate 1 infection status: 12 hpi;virus strain: strain 17, dl1403 followed ATACseq protocol GSM5608525 HSV-1 lacking expression of ICP0, replicate 2 infection status: 12 hpi;virus strain: strain 17, dl1403 followed ATACseq protocol GSM5608526 HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, replicate 1 infection status: 12 hpi;virus strain: strain F, R325 followed ATACseq protocol GSM5608527 HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, replicate 2 infection status: 12 hpi;virus strain: strain F, R325 followed ATACseq protocol GSM5608528 HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, replicate 3 infection status: 12 hpi;virus strain: strain F, R325 followed ATACseq protocol GSM5608529 HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, replicate 4 infection status: 12 hpi;virus strain: strain F, R325 followed ATACseq protocol GSM5608530 HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, +PAA, replicate 1 infection status: 12 hpi;treatment: PAA 300ug/ml;virus strain: strain F, R325 followed ATACseq protocol GSM5608531 HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, +PAA, replicate 2 infection status: 12 hpi;treatment: PAA 300ug/ml;virus strain: strain F, R325 followed ATACseq protocol GSM5608532 HSV-1 lacking expression of ICP27, KOS, replicate 1 infection status: 8 hpi;virus strain: strain KOS, 27LacZ followed ATACseq protocol GSM5608533 HSV-1 lacking expression of ICP27, KOS, replicate 2 infection status: 8 hpi;virus strain: strain KOS, 27LacZ followed ATACseq protocol GSM5608534 HSV-1 lacking expression of UL41, replicate 1 infection status: 8 hpi;virus strain: strain 17 followed ATACseq protocol GSM5608535 HSV-1 lacking expression of UL41, replicate 2 infection status: 8 hpi;virus strain: strain 17 followed ATACseq protocol
Platform	GPL18573  : Illumina NextSeq 500 (Homo sapiens)
Literature	37524699