Virus Dataset Detail

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Dataset Information
Accession GSE198809
Status 2023/8/30
Title Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Subcutaneous adipose tissue (SAT) is a critical regulator of systemic metabolic homeostasis. Persons with HIV (PWH) have an increased risk of metabolic diseases and have significant alterations in SAT immune cells compared with the general population. We generated a comprehensive SAT atlas from 59 PWH with a spectrum of metabolic diseases to characterize cellular compositional and transcriptional changes associated with glucose intolerance and demographic characteristics. In PWH, glucose intolerance was associated with increased lipid-associated macrophages, CD4+ and CD8+ T effector memory cells, and decreased perivascular macrophages. We observed a coordinated intercellular regulatory program enriched for genes related to inflammation and lipid-processing with glucose intolerance that was also present in diabetic HIV-negative persons. Finally, CD4+ tissue resident cells were most strongly associated with altered whole tissue expression of genes related to lipid and glucose metabolism. These data provide a comprehensive assessment of SAT immune cells that may contribute to glucose intolerance.
Samples
GSM ID Sample info Characteristics Description
GSM5957138 RNA: Adipose Tissue Biopsy, P5344_CW2 1 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5344_CW2
GSM5957139 ADT: Adipose Tissue Biopsy, P5344_CW2 1 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5344_CW2
GSM5957140 RNA: Adipose Tissue Biopsy, P5344_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5344_CW3
GSM5957141 ADT: Adipose Tissue Biopsy, P5344_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5344_CW3
GSM5957142 RNA: Adipose Tissue Biopsy, P5544_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5544_CW1
GSM5957143 ADT: Adipose Tissue Biopsy, P5544_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5544_CW1
GSM5957144 RNA: Adipose Tissue Biopsy, P5344_CW2 2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5544_CW2
GSM5957145 ADT: Adipose Tissue Biopsy, P5344_CW2 2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5544_CW2
GSM5957146 RNA: Adipose Tissue Biopsy, P5544_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5544_CW3
GSM5957147 ADT: Adipose Tissue Biopsy, P5544_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5544_CW3
GSM5957148 RNA: Adipose Tissue Biopsy, P5573_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5573_CW1
GSM5957149 ADT: Adipose Tissue Biopsy, P5573_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5573_CW1
GSM5957150 RNA: Adipose Tissue Biopsy, P5573_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5573_CW2
GSM5957151 ADT: Adipose Tissue Biopsy, P5573_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5573_CW2
GSM5957152 RNA: Adipose Tissue Biopsy, P5573_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5573_CW3
GSM5957153 ADT: Adipose Tissue Biopsy, P5573_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5573_CW3
GSM5957154 RNA: Adipose Tissue Biopsy, P5657_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5657_CW1
GSM5957155 ADT: Adipose Tissue Biopsy, P5657_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5657_CW1
GSM5957158 RNA: Adipose Tissue Biopsy, P5657_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5657_CW3
GSM5957159 ADT: Adipose Tissue Biopsy, P5657_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5657_CW3
GSM5957160 RNA: Adipose Tissue Biopsy, P5836_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5836_CW1
GSM5957161 ADT: Adipose Tissue Biopsy, P5836_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5836_CW1
GSM5957162 RNA: Adipose Tissue Biopsy, P5836_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5836_CW2
GSM5957163 ADT: Adipose Tissue Biopsy, P5836_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5836_CW2
GSM5957164 RNA: Adipose Tissue Biopsy, P5836_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5836_CW3
GSM5957165 ADT: Adipose Tissue Biopsy, P5836_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5836_CW3
GSM5957166 RNA: Adipose Tissue Biopsy, P5877_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5877_CW1
GSM5957167 ADT: Adipose Tissue Biopsy, P5877_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5877_CW1
GSM5957168 RNA: Adipose Tissue Biopsy, P5877_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5877_CW2
GSM5957169 ADT: Adipose Tissue Biopsy, P5877_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5877_CW2
GSM5957170 RNA: Adipose Tissue Biopsy, P5877_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5877_CW3
GSM5957171 ADT: Adipose Tissue Biopsy, P5877_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5877_CW3
GSM5957172 RNA: Adipose Tissue Biopsy, P5903_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5903_CW1
GSM5957173 ADT: Adipose Tissue Biopsy, P5903_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5903_CW1
GSM5957174 RNA: Adipose Tissue Biopsy, P5903_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5903_CW2
GSM5957175 ADT: Adipose Tissue Biopsy, P5903_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5903_CW2
GSM5957176 RNA: Adipose Tissue Biopsy, P5903_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5903_CW3
GSM5957177 ADT: Adipose Tissue Biopsy, P5903_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5903_CW3
GSM5957178 RNA: Adipose Tissue Biopsy, P5963_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5963_CW1
GSM5957179 ADT: Adipose Tissue Biopsy, P5963_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5963_CW1
GSM5957180 RNA: Adipose Tissue Biopsy, P5963_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5963_CW2
GSM5957181 ADT: Adipose Tissue Biopsy, P5963_CW2 disease state:HIV+ diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5963_CW2
GSM5957182 RNA: Adipose Tissue Biopsy, P5963_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5963_CW3
GSM5957183 ADT: Adipose Tissue Biopsy, P5963_CW3 disease state:HIV- diabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5963_CW3
GSM5957136 RNA: Adipose Tissue Biopsy, P5344_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5344_CW1
GSM5957137 ADT: Adipose Tissue Biopsy, P5344_CW1 disease state:HIV+ non-diabetic and HIV+ prediabetic; tissue:subcutaneous adipose tissue; number of donors:4 P5344_CW1
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
Literature 37711619  38820087  39657693  
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scRNA-seq UMAP