HIV Target gene Detail Information

> NISCH Gene Search Result


Gene Information
Gene Name NISCH
Gene ID 11188
Gene Full Name nischarin
Gene Alias I-1|IR1|IRAS|hIRAS
Transcripts ENSG00000010322
Virus HIV
Gene Type protein-coding
HPA Location Info Nucleoplasm, Cytosol;Vesicles, Microtubules, Cytokinetic bridge;
Membrane Info FDA approved drug targets, Predicted intracellular proteins
Uniport_ID Q9Y2I1
HGNC ID HGNC:18006
OMIM ID 615507
Summary This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
Target gene [NISCH] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4013689 chr3 2 1 0 3 View

Target gene [NISCH] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE221688 		Chip-seq;scATAC-Seq;scRNA-Seq 12 Illumina NovaSeq 6000 (Homo sapiens)
GSE99737 RNA-seq 9 Illumina HiSeq 2500 (Homo sapiens)
E
  GSE144332 		RNA-seq 75 NextSeq 550 (Homo sapiens)
C
  GSE165705 		Chip-seq 30 Illumina NovaSeq 6000 (Homo sapiens)
GSE164264 RNA-seq 6 BGISEQ-500 (Homo sapiens)
GSE262621 RNA-seq 70 Illumina NovaSeq 6000 (Homo sapiens)
GSE128121 RNA-seq 16 Illumina HiSeq 4000 (Homo sapiens)
GSE162914 RNA-seq 211 Illumina HiSeq 2500 (Homo sapiens)
GSE279982 Methylation profiling (Array) 576 Infinium MethylationEPIC
C
  GSE144329 		ATAC-seq 96 NextSeq 550 (Homo sapiens)
GSE205204 RNA-seq 14 Illumina NovaSeq 6000 (Homo sapiens)
GSE125686 RNA-seq 62 Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339 scRNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE220859 		Chip-seq 11 Illumina NovaSeq 6000 (Homo sapiens)
GSE165708 RNA-seq 100 Illumina HiSeq 4000 (Homo sapiens)
C
  GSE211651 		Chip-seq;RNA-seq;PRO-seq 39 Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028 MeDIP-chip 1 NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C
  GSE100376 		ATAC-seq 24 Illumina NextSeq 500 (Homo sapiens)
GSE167211 RNA-seq 1 Illumina HiSeq 2000 (Homo sapiens)
GSE165132 RNA-seq 56 NextSeq 550 (Homo sapiens)
C
  GSE100266 		ATAC-seq;Chip-seq;RNA-seq 32 Illumina HiSeq 2500 (Homo sapiens)
C
  GSE165703 		ATAC-seq 82 Illumina HiSeq 4000 (Homo sapiens)
GSE246082 RNA-seq 6 Illumina HiSeq 4000 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE144332 - NISCH expression across samples

Volcano Plot

Bar Plot