Gene Name	ARHGAP35
Gene ID	2909
Gene Full Name	Rho GTPase activating protein 35
Gene Alias	GRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP
Transcripts	ENSG00000160007
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Nuclear bodies;Microtubules, Aggresome;
Membrane Info	Cancer-related genes, Predicted intracellular proteins
Uniport_ID	Q9NRY4
HGNC ID	HGNC:4591
OMIM ID	605277
Summary	The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000311	chr19	73	260	223	556	View
4005120	chr19	25	7	3	35	View
4005121	chr19	25	7	3	35	View
4005122	chr19	25	7	3	35	View
4005123	chr19	25	7	3	35	View
4007201	chr19	11	5	3	19	View
4010047	chr19	10	0	0	10	View
4012276	chr19	5	0	0	5	View
4015084	chr19	1	0	0	1	View
4016723	chr19	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - ARHGAP35 peak across samples

Peak Plot

> Dataset: GSE165705 - ARHGAP35 peak across samples

Peak Plot

> Dataset: GSE30738 - ARHGAP35 peak across samples

Peak Plot

> Dataset: GSE144329 - ARHGAP35 peak across samples

Peak Plot

> Dataset: GSE220859 - ARHGAP35 peak across samples

Peak Plot

> Dataset: GSE211651 - ARHGAP35 peak across samples

Peak Plot

> Dataset: GSE100376 - ARHGAP35 peak across samples

Peak Plot

> Dataset: GSE100266 - ARHGAP35 peak across samples

Peak Plot

> Dataset: GSE165703 - ARHGAP35 peak across samples

Peak Plot