Gene Information
|
Gene Name
|
LAMB1 |
|
Gene ID
|
3912
|
|
Gene Full Name
|
laminin subunit beta 1 |
|
Gene Alias
|
CLM|LIS5 |
|
Transcripts
|
ENSG00000091136
|
|
Virus
|
HIV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Secreted to extracellular matrix; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
|
Uniport_ID
|
P07942
|
|
HGNC ID
|
HGNC:6486
|
|
OMIM ID
|
150240 |
|
Summary
|
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011] |
Target gene [LAMB1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 4012416 |
chr7 |
1 |
1 |
3 |
5 |
View |
Target gene [LAMB1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE99737
|
RNA-seq |
9 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE144332
|
RNA-seq |
75 |
NextSeq 550 (Homo sapiens) |
|
C GSE165705
|
Chip-seq |
30 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE164264
|
RNA-seq |
6 |
BGISEQ-500 (Homo sapiens) |
|
C GSE30738
|
Chip-seq |
2 |
Illumina Genome Analyzer II (Homo sapiens) |
|
GSE262621
|
RNA-seq |
70 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE128121
|
RNA-seq |
16 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE162914
|
RNA-seq |
211 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE279982
|
Methylation profiling (Array) |
576 |
Infinium MethylationEPIC |
|
C GSE144329
|
ATAC-seq |
96 |
NextSeq 550 (Homo sapiens) |
|
GSE205204
|
RNA-seq |
14 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE125686
|
RNA-seq |
62 |
Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
C GSE220859
|
Chip-seq |
11 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE165708
|
RNA-seq |
100 |
Illumina HiSeq 4000 (Homo sapiens) |
|
C GSE211651
|
Chip-seq;RNA-seq;PRO-seq |
39 |
Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE198809
|
scRNA-seq |
46 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE68028
|
MeDIP-chip |
1 |
NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1] |
|
C GSE100376
|
ATAC-seq |
24 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE167211
|
RNA-seq |
1 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE165132
|
RNA-seq |
56 |
NextSeq 550 (Homo sapiens) |
|
C GSE100266
|
ATAC-seq;Chip-seq;RNA-seq |
32 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE165703
|
ATAC-seq |
82 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE246082
|
RNA-seq |
6 |
Illumina HiSeq 4000 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE165705 - LAMB1 peak across samples
|
Peak Plot
|
> Dataset: GSE30738 - LAMB1 peak across samples
|
Peak Plot
|
> Dataset: GSE144329 - LAMB1 peak across samples
|
Peak Plot
|
> Dataset: GSE220859 - LAMB1 peak across samples
|
Peak Plot
|
> Dataset: GSE211651 - LAMB1 peak across samples
|
Peak Plot
|
> Dataset: GSE100376 - LAMB1 peak across samples
|
Peak Plot
|
> Dataset: GSE100266 - LAMB1 peak across samples
|
Peak Plot
|
> Dataset: GSE165703 - LAMB1 peak across samples
|
Peak Plot
|
|
|
HIV Target gene Detail Information
