Gene Name	ARHGEF6
Gene ID	9459
Gene Full Name	Rac/Cdc42 guanine nucleotide exchange factor 6
Gene Alias	COOL2|Cool-2|MRX46|PIXA|alpha-PIX|alphaPIX
Transcripts	ENSG00000129675
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Plasma membrane, Cytosol;
Membrane Info	Cancer-related genes, Predicted intracellular proteins
Uniport_ID	Q15052
HGNC ID	HGNC:685
OMIM ID	300267
Summary	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002165	chrX	28	69	11	108	View
4002680	chrX	82	2	0	84	View
4003467	chrX	56	3	2	61	View
4005768	chrX	2	28	0	30	View
4006001	chrX	28	0	0	28	View
4006133	chrX	27	0	0	27	View
4010621	chrX	0	8	0	8	View
4011940	chrX	6	0	0	6	View
4012521	chrX	5	0	0	5	View
4012791	chrX	2	2	0	4	View
4014034	chrX	0	3	0	3	View
4014582	chrX	2	0	0	2	View
4015160	chrX	1	0	0	1	View
4015161	chrX	1	0	0	1	View
4015568	chrX	1	0	0	1	View
4015727	chrX	1	0	0	1	View
4016459	chrX	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE148796	scRNA-seq	4	Illumina NextSeq 500 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - ARHGEF6 peak across samples

Peak Plot

> Dataset: GSE165705 - ARHGEF6 peak across samples

Peak Plot

> Dataset: GSE144329 - ARHGEF6 peak across samples

Peak Plot

> Dataset: GSE220859 - ARHGEF6 peak across samples

Peak Plot

> Dataset: GSE211651 - ARHGEF6 peak across samples

Peak Plot

> Dataset: GSE100376 - ARHGEF6 peak across samples

Peak Plot

> Dataset: GSE100266 - ARHGEF6 peak across samples

Peak Plot

> Dataset: GSE165703 - ARHGEF6 peak across samples

Peak Plot