Gene Information
|
Gene Name
|
BRAF |
|
Gene ID
|
673
|
|
Gene Full Name
|
B-Raf proto-oncogene, serine/threonine kinase |
|
Gene Alias
|
B-RAF1|B-raf|BRAF-1|BRAF1|NS7|RAFB1 |
|
Transcripts
|
ENSG00000157764
|
|
Virus
|
HIV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Vesicles, Cytosol;Plasma membrane, Primary cilium, Centriolar satellite, Basal body, Mid piece, Principal piece, End piece; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Transporters |
|
Uniport_ID
|
P15056
|
|
HGNC ID
|
HGNC:1097
|
|
OMIM ID
|
164757 |
|
Summary
|
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017] |
Target gene [BRAF] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 4008095 |
chr7 |
0 |
15 |
1 |
16 |
View |
| 4011635 |
chr7 |
6 |
0 |
0 |
6 |
View |
| 4014028 |
chr7 |
3 |
0 |
0 |
3 |
View |
| 4016415 |
chr7 |
0 |
0 |
0 |
0 |
View |
Target gene [BRAF] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE221688
|
Chip-seq;scATAC-Seq;scRNA-Seq |
12 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE99737
|
RNA-seq |
9 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE144332
|
RNA-seq |
75 |
NextSeq 550 (Homo sapiens) |
|
C GSE165705
|
Chip-seq |
30 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE164264
|
RNA-seq |
6 |
BGISEQ-500 (Homo sapiens) |
|
C GSE30738
|
Chip-seq |
2 |
Illumina Genome Analyzer II (Homo sapiens) |
|
GSE262621
|
RNA-seq |
70 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE128121
|
RNA-seq |
16 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE162914
|
RNA-seq |
211 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE187515
|
scRNA-seq |
104 |
Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE279982
|
Methylation profiling (Array) |
576 |
Infinium MethylationEPIC |
|
C GSE144329
|
ATAC-seq |
96 |
NextSeq 550 (Homo sapiens) |
|
GSE205204
|
RNA-seq |
14 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE125686
|
RNA-seq |
62 |
Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE198339
|
scRNA-seq |
8 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE220859
|
Chip-seq |
11 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE165708
|
RNA-seq |
100 |
Illumina HiSeq 4000 (Homo sapiens) |
|
C GSE211651
|
Chip-seq;RNA-seq;PRO-seq |
39 |
Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE198809
|
scRNA-seq |
46 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE68028
|
MeDIP-chip |
1 |
NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1] |
|
C GSE100376
|
ATAC-seq |
24 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE167211
|
RNA-seq |
1 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE165132
|
RNA-seq |
56 |
NextSeq 550 (Homo sapiens) |
|
C GSE100266
|
ATAC-seq;Chip-seq;RNA-seq |
32 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE165703
|
ATAC-seq |
82 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE246082
|
RNA-seq |
6 |
Illumina HiSeq 4000 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE221688 - BRAF peak across samples
|
Peak Plot
|
> Dataset: GSE165705 - BRAF peak across samples
|
Peak Plot
|
> Dataset: GSE30738 - BRAF peak across samples
|
Peak Plot
|
> Dataset: GSE144329 - BRAF peak across samples
|
Peak Plot
|
> Dataset: GSE220859 - BRAF peak across samples
|
Peak Plot
|
> Dataset: GSE211651 - BRAF peak across samples
|
Peak Plot
|
> Dataset: GSE100376 - BRAF peak across samples
|
Peak Plot
|
> Dataset: GSE100266 - BRAF peak across samples
|
Peak Plot
|
> Dataset: GSE165703 - BRAF peak across samples
|
Peak Plot
|
|
|
HIV Target gene Detail Information
