Gene Name	CREBBP
Gene ID	1387
Gene Full Name	CREB binding protein
Gene Alias	CBP|KAT3A|MKHK1|RSTS|RSTS1
Transcripts	ENSG00000005339
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Nuclear bodies;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q92793
HGNC ID	HGNC:2348
OMIM ID	600140
Summary	This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000151	chr16	61	387	424	872	View
4000170	chr16	99	381	348	828	View
4000171	chr16	99	381	348	828	View
4000275	chr16	123	154	327	604	View
4000454	chr16	43	325	84	452	View
4000644	chr16	134	139	61	334	View
4001048	chr16	196	19	10	225	View
4001093	chr16	62	46	108	216	View
4001120	chr16	163	45	3	211	View
4001757	chr16	134	0	0	134	View
4002189	chr16	105	1	1	107	View
4002205	chr16	12	87	7	106	View
4002239	chr16	25	63	15	103	View
4002729	chr16	34	37	11	82	View
4004114	chr16	5	40	4	49	View
4004650	chr16	26	7	8	41	View
4004734	chr16	35	1	4	40	View
4005417	chr16	20	5	8	33	View
4007441	chr16	15	4	0	19	View
4009652	chr16	7	4	0	11	View
4010492	chr16	1	7	1	9	View
4010950	chr16	1	6	1	8	View
4010951	chr16	1	6	1	8	View
4010952	chr16	1	6	1	8	View
4011574	chr16	6	0	0	6	View
4012068	chr16	5	0	0	5	View
4012901	chr16	4	0	0	4	View
4013096	chr16	4	0	0	4	View
4013794	chr16	2	1	0	3	View
4013865	chr16	2	1	0	3	View
4013866	chr16	1	2	0	3	View
4013867	chr16	3	0	0	3	View
4014385	chr16	2	0	0	2	View
4015047	chr16	1	0	0	1	View
4015291	chr16	1	0	0	1	View
4015516	chr16	1	0	0	1	View
4015620	chr16	1	0	0	1	View
4016228	chr16	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - CREBBP peak across samples

Peak Plot

> Dataset: GSE165705 - CREBBP peak across samples

Peak Plot

> Dataset: GSE30738 - CREBBP peak across samples

Peak Plot

> Dataset: GSE144329 - CREBBP peak across samples

Peak Plot

> Dataset: GSE220859 - CREBBP peak across samples

Peak Plot

> Dataset: GSE211651 - CREBBP peak across samples

Peak Plot

> Dataset: GSE100376 - CREBBP peak across samples

Peak Plot

> Dataset: GSE100266 - CREBBP peak across samples

Peak Plot

> Dataset: GSE165703 - CREBBP peak across samples

Peak Plot