Overview of CHIKV Mutation, Integration-Cistrome Factor Overlap and Target gene

Chikungunya Virus (CHIKV) is a member of the genus Alphavirus, and family Togaviridae. Chikungunya virus features an icosahedral capsid surrounded by a lipid envelope, with a diameter ranging from 60 to 70 nm. It was first isolated in 1953 in Tanzania and is an RNA virus with a positive-sense single-stranded genome of about 11.6kb. It is a member of the Semliki Forest virus complex and is closely related to Ross River virus, O'nyong'nyong virus, and Semliki Forest virus.
Size: 12kb
Encoding: 6K, C, E1, E2, E3, nsP1, nsP2, nsP3, nsP4, Pol, etc.
Human Disease: Chikungunya Fever, etc.
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CHIKV Mutation Info

Click here to see all CHIKV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	20417142	A226V	E1	E1	Chikungunya Fever	G S C L	View
2	30126424	A47T	6K		Chikungunya Fever	G R	View
3	30126424	A55V	C	Capsid	Chikungunya Fever	G R	View
4	30126424	A93V	C	Capsid	Chikungunya Fever	G R	View
5	30126424	Q37K	C	Capsid	Chikungunya Fever	G R	View
6	30126424	Q78R	C	Capsid	Chikungunya Fever	G R	View
7	30126424	A225S	E1	E1	Chikungunya Fever	G R	View
8	30126424	A321T	E1	E1	Chikungunya Fever	G R	View
9	30126424	A98T	E1	E1	Chikungunya Fever	G R	View
10	30126424	K211E	E1	E1	Chikungunya Fever	G R	View
11	30126424	L397P	E1	E1	Chikungunya Fever	G R	View
12	30126424	N72S	E1	E1	Chikungunya Fever	G R	View
13	30126424	P304S	E1	E1	Chikungunya Fever	G R	View
14	30126424	T145A	E1	E1	Chikungunya Fever	G R	View
15	30126424	G205D	E2	E2	Chikungunya Fever	G R	View
16	30126424	G79E	E2	E2	Chikungunya Fever	G R	View
17	30126424	H5N	E2	E2	Chikungunya Fever	G R	View
18	30126424	I255V	E2	E2	Chikungunya Fever	G R	View
19	30126424	K149R	E2	E2	Chikungunya Fever	G R	View
20	30126424	K57G	E2	E2	Chikungunya Fever	G R	View
21	30126424	L248S	E2	E2	Chikungunya Fever	G R	View
22	30126424	M74I	E2	E2	Chikungunya Fever	G R	View
23	30126424	N207S	E2	E2	Chikungunya Fever	G R	View
24	30126424	Q307R	E2	E2	Chikungunya Fever	G R	View
25	30126424	S118G	E2	E2	Chikungunya Fever	G R	View
26	30126424	V157A	E2	E2	Chikungunya Fever	G R	View
27	30126424	V317I	E2	E2	Chikungunya Fever	G R	View
28	30126424	V318R	E2	E2	Chikungunya Fever	G R	View
29	30126424	V370A	E2	E2	Chikungunya Fever	G R	View
30	30126424	R60H	E3	E3	Chikungunya Fever	G R	View
31	30126424	S44R	E3	E3	Chikungunya Fever	G R	View
32	30126424	T23I	E3	E3	Chikungunya Fever	G R	View
33	30126424	D486N	nsP1	nsP1	Chikungunya Fever	G R	View
34	30126424	L507H	nsP1	nsP1	Chikungunya Fever	G R	View
35	30126424	P34S	nsP1	nsP1	Chikungunya Fever	G R	View
36	30126424	R491Q	nsP1	nsP1	Chikungunya Fever	G R	View
37	30126424	S454G	nsP1	nsP1	Chikungunya Fever	G R	View
38	30126424	S473R	nsP1	nsP1	Chikungunya Fever	G R	View
39	30126424	T478A	nsP1	nsP1	Chikungunya Fever	G R	View
40	30126424	C642Y	nsP2	nsP2	Chikungunya Fever	G R	View
41	30126424	I486V	nsP2	nsP2	Chikungunya Fever	G R	View
42	30126424	N768S	nsP2	nsP2	Chikungunya Fever	G R	View
43	30126424	P16L	nsP2	nsP2	Chikungunya Fever	G R	View
44	30126424	Q273L	nsP2	nsP2	Chikungunya Fever	G R	View
45	30126424	T218S	nsP2	nsP2	Chikungunya Fever	G R	View
46	30126424	V756I	nsP2	nsP2	Chikungunya Fever	G R	View
47	30126424	A334V	nsP3	nsP3	Chikungunya Fever	G R	View
48	30126424	E484D	nsP3	nsP3	Chikungunya Fever	G R	View
49	30126424	I343T	nsP3	nsP3	Chikungunya Fever	G R	View
50	30126424	K342E	nsP3	nsP3	Chikungunya Fever	G R	View
51	30126424	L434Q	nsP3	nsP3	Chikungunya Fever	G R	View
52	30126424	M449I	nsP3	nsP3	Chikungunya Fever	G R	View
53	30126424	N483D	nsP3	nsP3	Chikungunya Fever	G R	View
54	30126424	Q332R	nsP3	nsP3	Chikungunya Fever	G R	View
55	30126424	Q452R	nsP3	nsP3	Chikungunya Fever	G R	View
56	30126424	R524G	nsP3	nsP3	Chikungunya Fever	G R	View
57	30126424	V166I	nsP3	nsP3	Chikungunya Fever	G R	View
58	30126424	V339A	nsP3	nsP3	Chikungunya Fever	G R	View
59	30126424	V437A	nsP3	nsP3	Chikungunya Fever	G R	View
60	30126424	A43L	nsP4	nsP4	Chikungunya Fever	G R	View
61	30126424	E280D	nsP4	nsP4	Chikungunya Fever	G R	View
62	30126424	I101V	nsP4	nsP4	Chikungunya Fever	G R	View
63	30126424	K271R	nsP4	nsP4	Chikungunya Fever	G R	View
64	30126424	Q235R	nsP4	nsP4	Chikungunya Fever	G R	View
65	30126424	R85K	nsP4	nsP4	Chikungunya Fever	G R	View
66	30126424	S90A	nsP4	nsP4	Chikungunya Fever	G R	View
67	30126424	T366A	nsP4	nsP4	Chikungunya Fever	G R	View
68	30126424	V582A	nsP4	nsP4	Chikungunya Fever	G R	View
69	30126424	V604I	nsP4	nsP4	Chikungunya Fever	G R	View
70	30126424	Y107H	nsP4	nsP4	Chikungunya Fever	G R	View
71	31292455	R78Q	C	Capsid	Chikungunya Fever	G S C L	View
72	27423270	K211E	E1	E1	Chikungunya Fever	G R	View
73	27430542	V371L	E2	E2	Chikungunya Fever	G S	View
74	35062275	S248F	E2	E2	Chikungunya Fever	G R L	View
75	31292455	A153V	nsP2	nsP2	Chikungunya Fever	G S C L	View
76	31292455	G720A	nsP2	nsP2	Chikungunya Fever	G S C L	View
77	31292455	Y543H	nsP2	nsP2	Chikungunya Fever	G S C L	View
78	31292455	L458P	nsP3	nsP3	Chikungunya Fever	G S C L	View
79	35062275	A437T	nsP3	nsP3	Chikungunya Fever	G R L	View
80	27430542	K211E	E1	E1	Chikungunya Fever	G S L	View
81	35385544	A9496G	E2	E2	Chikungunya Fever	G R L	View
82	35385544	T669A	E2	E2	Chikungunya Fever	G R L	View
83	35385544	V368A	E2	E2	Chikungunya Fever	G R L	View
84	35385544	G1255A	nsP2	nsP2	Chikungunya Fever	G R L	View
85	35385544	G3764C	nsP2	nsP2	Chikungunya Fever	G R L	View
86	35385544	T3232C	nsP2	nsP2	Chikungunya Fever	G R L	View
87	35385544	Y1078H	nsP2	nsP2	Chikungunya Fever	G R L	View
88	26781948	L20M	6K		Chikungunya Fever	G R L	View
89	27430542	A98T	E1	E1	Chikungunya Fever	G S	View
90	26781948	V368A	E2	E2	Chikungunya Fever	G R	View
91	27430542	L20M	6K		Chikungunya Fever	G S	View
92	27430542	V368A	E2	E2	Chikungunya Fever	G S	View
93	27430542	L248F	E2	E2	Chikungunya Fever	G S	View
94	27430542	A47T	6K		Chikungunya Fever	G S	View
95	30860010	A98T	E1	E1	Chikungunya Fever	G S	View
96	30860010	V326M	nsP1	nsP1	Chikungunya Fever	G S	View
97	30860010	S18F	E3	E3	Chikungunya Fever	G S	View
98	30860010	G230R	nsP1	nsP1	Chikungunya Fever	G S	View
99	30860010	X524R	nsP3	nsP3	Chikungunya Fever	G S	View
100	35062275	T145A	E1	E1	Chikungunya Fever	G R	View

Contents
Description

The table shows all curated mutation sites of CHIKV in each literature

Table Description Column Note

D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.

G
The study mentioned the virus genotype/subtype information.

R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.

S
The study provided sequence information or accession numbers.

L
The study provided the geographic region/country of data origin.

C
The study provided clinical baseline information.

I
The study involved information related to immune.

T
The study involved host target genes.

CHIKV Target Gene Info

Only show 100 info Click here to see all CHIKV Target Gene

ID	Target gene	Virus	Impact	Literature Count	Detail
1	CCL2	CHIKV	M	1	View
2	CXCL10	CHIKV	M	1	View
3	HPRT1	CHIKV	M	1	View
4	IFNB1	CHIKV	M	1	View
5	IL6	CHIKV	M	1	View
6	IRAK1	CHIKV	M	1	View
7	IRAK2	CHIKV	M	1	View
8	IRF1	CHIKV	M	1	View
9	IRF3	CHIKV	M	2	View
10	IRF7	CHIKV	M	2	View
11	ISG15	CHIKV	M	1	View
12	MX2	CHIKV	M	1	View
13	MXRA8	CHIKV	M	1	View
14	MYD88	CHIKV	M	1	View
15	OAS3	CHIKV	M	1	View
16	TICAM1	CHIKV	M	1	View
17	TLR3	CHIKV	M	1	View
18	TLR7	CHIKV	M	1	View
19	TLR8	CHIKV	M	1	View
20	TLR9	CHIKV	M	1	View
21	TRAF6	CHIKV	M	2	View

Contents Description and
Data Download

Table Note

I
Target gene is affected by virus integration.

M
Target gene is associated with the virus gene/protein/region.

E
Target gene is detected in the expression profiling data.

S
Target gene is detected in the single-cell transcriptome data.

C
Target gene is detected in the genome binding/occupancy profiling data.

M
Target gene is detected in the methylation profiling data.

F
Target gene provides figures to visualize the analysis results.
F indicates that this gene has visualization results on at least one type of sequencing data.