Overview of KSHV Mutation, Integration-Cistrome Factor Overlap and Target gene

Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is the ninth known human herpesvirus. It is also called Human herpesvirus 8, or HHV-8 in short. This virus causes Kaposi's sarcoma, a cancer commonly occurring in AIDS patients, as well as primary effusion lymphoma, HHV-8-associated multicentric Castleman's disease and KSHV inflammatory cytokine syndrome.
Size: 165kb
Encoding: ORF29, ORF57, RTA, SOX, etc.
Click the View button on the page to view detailed information.

KSHV Mutation Info

Click here to see all KSHV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	17850910	K152E	RTA	ORF50	Cell line	T	View
2	22300411	T366A	RTA	ORF50	Cell line	I T	View
3	22300411	T367A	RTA	ORF50	Cell line	I T	View
4	23678174	S376A	ORF59	ORF59	Cell line		View
5	23678174	S378A	ORF59	ORF59	Cell line		View
6	23678174	S379A	ORF59	ORF59	Cell line		View
7	23804715	A57L	vFLIP	HHV8GK18_gp80	Cell line	T	View
8	25320298	F66A	ORF45	ORF45	Cell line	R I T	View
9	26650119	K297R	ORF45	ORF45	Cell line		View
10	30061278	D476A	ORF29	ORF29	Cell line		View
11	30061278	D661A	ORF29	ORF29	Cell line		View
12	30061278	D662A	ORF29	ORF29	Cell line		View
13	30061278	E550A	ORF29	ORF29	Cell line		View
14	30728255	Q129H	ORF37	ORF37	Cell line		View
15	30842327	F66A	ORF45	ORF45	Cell line	D I T	View
16	34578410	W403A	C19	ORF45	Cell line		View
17	34578410	W405A	C19	ORF45	Cell line		View
18	36674756	ORF21 deletion	ORF21	ORF21	Cell line	R T	View
19	36674756	21KD	ORF21	ORF21	Cell line	R T	View
20	37364111	F444A	SOX	ORF37	Cell line	I T	View
21	37364111	Y443A	SOX	ORF37	Cell line	I T	View
22	38619650	R136Q	ORF42	ORF42	Cell line	R L	View
23	20419159	K5delRING	K5	K5	Cell line	T	View
24	22022268	P176S	SOX	ORF37	Cell line		View
25	22022268	Q129H	SOX	ORF37	Cell line		View
26	23990779	H145L	RTA	ORF50	Cell line	R T	View
27	29432452	E52K	gH	ORF22	Cell line	R T	View
28	29432452	F53A	gH	ORF22	Cell line	R T	View
29	29432452	I49A	gL	ORF47	Cell line	R	View
30	29432452	L47A	gL	ORF47	Cell line	R	View
31	29432452	L60A	gL	ORF47	Cell line	R T	View
32	29432452	W62A	gL	ORF47	Cell line	R T	View
33	30096191	K345A	ORF57	ORF57	Cell line	S	View
34	30096191	R270A	ORF57	ORF57	Cell line	S	View
35	30096191	R271A	ORF57	ORF57	Cell line	S	View
36	30096191	R325A	ORF57	ORF57	Cell line	S	View
37	30096191	R327A	ORF57	ORF57	Cell line	S	View
38	30096191	W292P	ORF57	ORF57	Cell line	S	View
39	37068108	D476A	ORF29	ORF29	Cell line		View
40	37068108	E321K	ORF29	ORF29	Cell line		View
41	37068108	ORF29 deletion	ORF29	ORF29	Cell line		View
42	37068108	G226A	ORF29	ORF29	Cell line		View
43	39818969	D470P	gB	ORF8	Cell line	R	View
44	39818969	G471P	gB	ORF8	Cell line	R	View

Contents
Description

The table shows all curated mutation sites of KSHV in each literature

Table Description Column Note

D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.

G
The study mentioned the virus genotype/subtype information.

R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.

S
The study provided sequence information or accession numbers.

L
The study provided the geographic region/country of data origin.

C
The study provided clinical baseline information.

I
The study involved information related to immune.

T
The study involved host target genes.

KSHV Target Gene Info

Only show 100 info Click here to see all KSHV Target Gene

ID	Target gene	Virus	Impact	Literature Count	Description	Detail
1	AIM2	KSHV	M	1	E C	View
2	BST2	KSHV	M	1	E C	View
3	CASP1	KSHV	M	1	E C	View
4	EGFR	KSHV	M	1	E C	View
5	EPHA2	KSHV	M	1	E C	View
6	IFIT3	KSHV	M	1	E C	View
7	IL1B	KSHV	M	1	E C	View
8	IRF4	KSHV	M	1	E C	View
9	MAP2K7	KSHV	M	1	E C	View
10	MAPK1	KSHV	M	2	E C	View
11	NFKB1	KSHV	M	1	E C	View
12	NOTCH1	KSHV	M	1	E C	View
13	PARP1	KSHV	M	1	E C	View
14	RBPJ	KSHV	M	1	E C	View
15	RPS6KA3	KSHV	M	2	E C	View
16	RSAD2	KSHV	M	1	E C	View
17	SUMO1	KSHV	M	1	E C	View
18	SUMO2	KSHV	M	1	E C	View
19	SUMO3	KSHV	M	1	E C	View

Contents Description and
Data Download

Table Note

I
Target gene is affected by virus integration.

M
Target gene is associated with the virus gene/protein/region.

E
Target gene is detected in the expression profiling data.

S
Target gene is detected in the single-cell transcriptome data.

C
Target gene is detected in the genome binding/occupancy profiling data.

M
Target gene is detected in the methylation profiling data.

F
Target gene provides figures to visualize the analysis results.
F indicates that this gene has visualization results on at least one type of sequencing data.