Overview of HPV Mutation, Integration-Cistrome Factor Overlap and Target gene

Human Papillomavirus (HPV) is a small double-stranded circular DNA virus with a genome of approximately 8000 base pairs. The HPV life cycle strictly follows the differentiation program of the host keratinocyte. It is thought that the HPV virion infects epithelial tissues through micro-abrasions, whereby the virion associates with putative receptors such as alpha integrins, laminins, and annexin A2 leading to the entry of the virions into basal epithelial cells through clathrin-mediated endocytosis and/or caveolin-mediated endocytosis depending on the type of HPV.
Size: 8kb
Encoding: E1, E1^E4, E2, E5, E6, E7, L1, L2, etc.
Human Disease: Uterine Cervical Neoplasms, Cervical Intraepithelial Neoplasia, Squamous Intraepithelial Lesions, Uterine Cervicitis, etc.
Click the View button on the page to view detailed information.


HPV Mutation Info
Only show 100 info Click here to see all HPV Mutation Sites
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 35086475 F458L
L1
L1
Uterine Cervical Neoplasms
G
C
L
View
2 32986347 S49N
L1
L1
Uterine Cervical Neoplasms
G
R
L
View
3 23451059 C2858G
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
4 25111286 A532G
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
5 25111286 A95G
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
6 25111286 C335T
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
7 25111286 C549A
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
8 25111286 D25E
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
9 25111286 E113D
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
10 25111286 G145T
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
11 25111286 G188C
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
12 25111286 G267A
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
13 25111286 G94A
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
14 23451059 C3084G
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
15 25111286 H78Y
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
16 25111286 L83V
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
17 25111286 N58S
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
18 25111286 T178A
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
19 25111286 T178G
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
20 25111286 T183C
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
21 25111286 T185G
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
22 25111286 T286A
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
23 25111286 T350G
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
24 25111286 T485C
E6
E6
Uterine Cervical Neoplasms
G
R
S
C
L
View
25 23451059 C3275G
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
26 28036379 I27R
E6
E6
Uterine Cervical Neoplasms
G
R
L
View
27 28036379 T183G
E6
E6
Uterine Cervical Neoplasms
G
R
L
View
28 29783960 Q6R
E6
E6
Uterine Cervical Neoplasms
G
C
View
29 30981880 A131C
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
30 30981880 R10R
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
31 32308546 A49C
E6
E6
Uterine Cervical Neoplasms
G
R
L
View
32 32308546 C13T
E6
E6
Uterine Cervical Neoplasms
G
R
L
View
33 32308546 T24C
E6
E6
Uterine Cervical Neoplasms
G
R
L
View
34 35193568 D64E
E6
E6
Uterine Cervical Neoplasms
G
S
C
L
View
35 35193568 L83V
E6
E6
Uterine Cervical Neoplasms
G
S
C
L
View
36 23451059 G2857C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
37 35193568 T295G
E6
E6
Uterine Cervical Neoplasms
G
S
C
L
View
38 35193568 T350G
E6
E6
Uterine Cervical Neoplasms
G
S
C
L
View
39 36680149 L83V
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
40 38520797 A131G
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
41 38520797 C335T
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
42 38520797 D25E
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
43 38520797 H78Y
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
44 38520797 L83V
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
45 38520797 Q14H
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
46 38520797 R10G
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
47 23451059 G2859T
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
48 38520797 T178G
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
49 38520797 T350G
E6
E6
Uterine Cervical Neoplasms
G
R
C
L
View
50 38158635 C3979A
E5
E5
Uterine Cervical Neoplasms
G
R
S
L
View
51 38158635 C3991T
E5
E5
Uterine Cervical Neoplasms
G
R
S
L
View
52 38158635 G4017A
E5
E5
Uterine Cervical Neoplasms
G
R
S
L
View
53 38158635 G4042A
E5
E5
Uterine Cervical Neoplasms
G
R
S
L
View
54 22524831 A2926G
E2
E2
Uterine Cervical Neoplasms
G
R
S
View
55 22524831 C3410T
E2
E2
Uterine Cervical Neoplasms
G
R
S
View
56 22524831 G2826A
E2
E2
Uterine Cervical Neoplasms
G
R
S
View
57 30008422 A143T
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
58 23451059 G3085C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
59 30008422 A3181C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
60 30008422 A3362G
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
61 30008422 A3538C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
62 30008422 C251F
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
63 30008422 C2860A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
64 30008422 C3377G
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
65 30008422 C3516A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
66 30008422 D173E
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
67 30008422 D173N
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
68 30008422 E142D
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
69 23451059 R649V
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
70 30008422 F168Y
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
71 30008422 F271V
E2
E2
Uterine Cervical Neoplasms
G
R
I
L
View
72 30008422 G150G
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
73 30008422 G3182A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
74 30008422 G3272A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
75 30008422 G3307T
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
76 30008422 G3507T
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
77 30008422 G3778T
E2
E2
Uterine Cervical Neoplasms
G
R
I
L
View
78 30008422 H35Q
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
79 30008422 I211T
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
80 23451059 R90A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
81 30008422 L157I
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
82 30008422 N203D
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
83 30008422 P208A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
84 30008422 S261S
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
85 30008422 S274A
E2
E2
Uterine Cervical Neoplasms
G
R
I
L
View
86 30008422 S317S
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
87 30008422 T254N
E2
E2
Uterine Cervical Neoplasms
G
R
I
L
View
88 30008422 T313T
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
89 30008422 T3205C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
90 30008422 T3224A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
91 23451059 T2856C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
92 30008422 T3258A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
93 30008422 T3274G
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
94 30008422 T3387C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
95 30008422 T3517C
E2
E2
Uterine Cervical Neoplasms
G
R
I
L
View
96 30008422 T3566G
E2
E2
Uterine Cervical Neoplasms
G
R
I
L
View
97 30008422 T3575G
E2
E2
Uterine Cervical Neoplasms
G
R
I
L
View
98 30008422 T3664C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
99 30008422 T3694A
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
100 30008422 T3706C
E2
E2
Uterine Cervical Neoplasms
G
R
L
View
Contents
Description

The table shows all curated mutation sites of HPV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.

HPV Overlap Info between Viral Integration Fragments and Cistrome Factors
Only show 100 info Click here to see all HPV Integration Sites
DVID Chromosome Histone Modification Transcription Factor Binding Site Chromatin Accessibility Sum of Overlapped Records Detail
5012006 chr1 3516 8986 1997 14499 View
5006669 chr1 3861 2799 1704 8364 View
5014629 chr1 4400 2543 1172 8115 View
5012389 chr1 4255 2450 1128 7833 View
5000052 chr1 3679 2585 1312 7576 View
5000050 chr1 3624 2491 1281 7396 View
5012319 chr1 4381 1970 667 7018 View
5014624 chr1 2878 2038 1368 6284 View
5000039 chr1 2140 1554 1635 5329 View
5012391 chr1 3251 917 821 4989 View
5012392 chr1 3261 898 803 4962 View
5012361 chr1 3665 635 199 4499 View
5012390 chr1 808 1574 1971 4353 View
5012353 chr1 2653 877 688 4218 View
5012372 chr1 3155 459 433 4047 View
5012297 chr1 2911 756 177 3844 View
5012397 chr1 557 1817 1463 3837 View
5016984 chr1 2226 689 786 3701 View
5012306 chr1 3067 331 129 3527 View
5012307 chr1 3065 326 122 3513 View
5016940 chr1 191 1784 1238 3213 View
5014634 chr1 2662 350 129 3141 View
5012371 chr1 2734 135 205 3074 View
5000094 chr1 1585 675 777 3037 View
5006457 chr1 654 1831 348 2833 View
5012305 chr1 2584 198 41 2823 View
5007336 chr1 634 1808 357 2799 View
5007709 chr1 2267 205 246 2718 View
5008103 chr1 714 1737 200 2651 View
5000092 chr1 2405 92 147 2644 View
5014622 chr1 209 1316 1022 2547 View
5016983 chr1 2062 220 186 2468 View
5014625 chr1 2163 160 43 2366 View
5000103 chr1 217 1084 1023 2324 View
5012289 chr1 1063 847 409 2319 View
5012438 chr1 996 760 557 2313 View
5008770 chr1 182 1127 987 2296 View
5006446 chr1 464 1550 274 2288 View
5000107 chr1 241 1043 970 2254 View
5000108 chr1 154 1056 981 2191 View
5000109 chr1 154 1054 981 2189 View
5012464 chr1 1271 532 386 2189 View
5000110 chr1 255 1012 905 2172 View
5012340 chr1 1652 224 210 2086 View
5012339 chr1 1642 222 208 2072 View
5012370 chr1 1906 46 59 2011 View
5000116 chr1 268 884 812 1964 View
5012311 chr1 29 1081 817 1927 View
5012267 chr1 1397 332 92 1821 View
5012310 chr1 1114 616 44 1774 View
5012266 chr1 1276 375 84 1735 View
5014549 chr1 1598 37 11 1646 View
5014550 chr1 1586 38 12 1636 View
5012338 chr1 1387 103 120 1610 View
5000130 chr1 11 772 784 1567 View
5007325 chr1 267 1016 208 1491 View
5007337 chr1 261 969 242 1472 View
5012401 chr1 1371 67 2 1440 View
5012454 chr1 683 505 185 1373 View
5007335 chr1 397 871 62 1330 View
5012284 chr1 825 260 223 1308 View
5012321 chr1 61 751 474 1286 View
5012309 chr1 206 797 171 1174 View
5012378 chr1 232 517 403 1152 View
5000148 chr1 264 347 513 1124 View
5014513 chr1 537 507 73 1117 View
5014627 chr1 1094 19 1 1114 View
5012337 chr1 948 53 76 1077 View
5006554 chr1 147 768 115 1030 View
5006107 chr1 228 319 450 997 View
5012279 chr1 658 263 74 995 View
5014518 chr1 170 291 525 986 View
5014517 chr1 159 294 526 979 View
5014656 chr1 399 391 185 975 View
5012304 chr1 856 83 20 959 View
5000165 chr1 176 491 279 946 View
5012316 chr1 570 114 168 852 View
5012317 chr1 568 113 167 848 View
5012282 chr1 689 67 70 826 View
5012283 chr1 690 67 69 826 View
5012369 chr1 750 16 2 768 View
5014626 chr1 718 14
0
732 View
5014521 chr1 527 81 104 712 View
5000231 chr1 150 259 302 711 View
5014609 chr1 94 299 304 697 View
5000190 chr1 203 151 340 694 View
5012440 chr1 621 50 22 693 View
5000192 chr1 11 550 130 691 View
5008486 chr1 261 407 18 686 View
5014581 chr1 49 330 305 684 View
5014520 chr1 508 81 91 680 View
5008666 chr1 39 54 567 660 View
5000195 chr1 646 12 1 659 View
5000196 chr1 631 23 5 659 View
5006467 chr1 203 359 97 659 View
5007002 chr1 635 11
0
646 View
5016986 chr1 245 281 106 632 View
5016955 chr1 484 118 29 631 View
5016956 chr1 479 117 29 625 View
5012441 chr1 558 36 13 607 View

Click to see histogram of VIS-Factor Overlap by chromosome of HPV

Click to see the overlap count of three factors and HPV intergration fragments on the human chromosomes


HPV Target Gene Info
Only show 100 info Click here to see all HPV Target Gene
ID Target gene Virus Impact Literature Count Description Detail
1 A2M HPV
I
1
E
S
C
M
View
2 AACS HPV
I
1
E
C
M
View
3 AACSP1 HPV
I
2
E
C
M
View
4 AADACL2-AS1 HPV
I
2
E
C
M
View
5 AAK1 HPV
I
1
E
S
C
M
View
6 AARS1 HPV
I
1
E
C
View
7 ABCA1 HPV
I
2
E
S
C
M
View
8 ABCA13 HPV
I
3
E
C
M
View
9 ABCA3 HPV
I
2
E
C
M
View
10 ABCA5 HPV
I
1
E
S
C
M
View
11 ABCA7 HPV
I
1
E
C
M
View
12 ABCB5 HPV
I
2
E
C
M
View
13 ABCB7 HPV
I
1
E
S
C
M
View
14 ABCC1 HPV
I
1
E
S
C
M
View
15 ABCC12 HPV
I
2
E
C
M
View
16 ABCC3 HPV
I
2
E
S
C
M
View
17 ABCC4 HPV
I
1
E
S
C
M
View
18 ABCC6P1 HPV
I
1
E
C
M
View
19 ABCC8 HPV
I
1
E
C
M
View
20 ABCD3 HPV
I
1
E
C
M
View
21 ABCG1 HPV
I
2
E
S
C
M
View
22 ABHD12 HPV
I
1
E
S
C
M
View
23 ABHD17B HPV
I
4
E
S
C
M
View
24 ABHD2 HPV
I
1
E
S
C
M
View
25 ABHD3 HPV
I
2
E
S
C
M
View
26 ABL1 HPV
I
1
E
S
C
M
View
27 ABL2 HPV
I
1
E
S
C
M
View
28 ABLIM1 HPV
I
4
E
S
C
M
View
29 ABLIM3 HPV
I
1
E
S
C
M
View
30 ABR HPV
I
4
E
S
C
M
View
31 ABTB2 HPV
I
1
E
S
C
M
View
32 ABTB3 HPV
I
2
E
C
View
33 AC006196.1 HPV
I
1 View
34 AC009965.1 HPV
I
1
E
View
35 AC011513.4 HPV
I
1 View
36 AC013463.2 HPV
I
1 View
37 AC018462.2 HPV
I
1
E
View
38 AC018799.1 HPV
I
1 View
39 AC019118.3 HPV
I
1 View
40 AC074286.1 HPV
I
1
E
View
41 AC079163.1 HPV
I
1
E
View
42 AC079248.1 HPV
I
1
E
View
43 AC079305.11 HPV
I
1 View
44 AC093334.1 HPV
I
1
E
View
45 AC112518.3 HPV
I
1 View
46 AC131056.3 HPV
I
1 View
47 ACAA2 HPV
I
2
E
S
C
M
View
48 ACACA HPV
I
1
E
C
M
View
49 ACACB HPV
I
1
E
S
C
M
View
50 ACAN HPV
I
1
E
S
C
M
View
51 ACBD6 HPV
I
2
E
S
C
M
View
52 ACE HPV
I
1
E
S
C
M
View
53 ACER3 HPV
I
1
E
S
C
M
View
54 ACO1 HPV
I
2
E
S
C
M
View
55 ACOT11 HPV
I
1
E
C
M
View
56 ACOT12 HPV
I
1
E
C
M
View
57 ACOXL HPV
I
2
E
C
M
View
58 ACSL1 HPV
I
1
E
S
C
M
View
59 ACSL3 HPV
I
1
E
S
C
M
View
60 ACSL6 HPV
I
1
E
C
M
View
61 ACSM2A HPV
I
1
E
M
View
62 ACSM5 HPV
I
1
E
C
M
View
63 ACSM6 HPV
I
1
E
C
M
View
64 ACSS1 HPV
I
1
E
C
M
View
65 ACSS2 HPV
I
1
E
S
C
M
View
66 ACTBL2 HPV
I
1
E
C
M
View
67 ACTL10 HPV
I
1
E
C
M
View
68 ACTL6A HPV
I
1
E
S
C
M
View
69 ACTL7B HPV
I
2
E
C
M
View
70 ACTL8 HPV
I
1
E
C
M
View
71 ACTL9 HPV
I
1
E
C
M
View
72 ACTN2 HPV
I
1
E
C
M
View
73 ACTR2 HPV
I
1
E
S
C
M
View
74 ACTR3BP2 HPV
I
3
E
View
75 ACTR3BP5 HPV
I
1
E
C
View
76 ACTR5 HPV
I
2
E
C
M
View
77 ACTRC3 HPV
I
1 View
78 ACTRT1 HPV
I
2
E
C
View
79 ACTRT2 HPV
I
1
E
C
M
View
80 ACVR2A HPV
I
2
E
C
M
View
81 ACVR2B HPV
I
1
E
C
M
View
82 ACYP1 HPV
I
1
E
S
C
M
View
83 ACYP2 HPV
I
1
E
S
C
M
View
84 ADA2 HPV
I
1
E
S
C
View
85 ADAM10 HPV
I
2
E
S
C
M
View
86 ADAM12 HPV
I
1
E
S
C
M
View
87 ADAM19 HPV
I
1
E
S
C
M
View
88 ADAM2 HPV
I
1
E
C
M
View
89 ADAM20P1 HPV
I
1
E
C
M
View
90 ADAM22 HPV
I
1
E
C
M
View
91 ADAM23 HPV
I
3
E
C
M
View
92 ADAM28 HPV
I
2
E
S
C
M
View
93 ADAM32 HPV
I
2
E
C
M
View
94 ADAM33 HPV
I
1
E
S
C
M
View
95 ADAM3A HPV
I
1
E
C
M
View
96 ADAM5 HPV
I
1
E
C
M
View
97 ADAMTS10 HPV
I
1
E
S
C
M
View
98 ADAMTS12 HPV
I
1
E
S
C
M
View
99 ADAMTS15 HPV
I
1
E
C
M
View
100 ADAMTS17 HPV
I
1
E
C
M
View
Contents Description and
Data Download
Table Note
I
Target gene is affected by virus integration.
M
Target gene is associated with the virus gene/protein/region.
E
Target gene is detected in the expression profiling data.
S
Target gene is detected in the single-cell transcriptome data.
C
Target gene is detected in the genome binding/occupancy profiling data.
M
Target gene is detected in the methylation profiling data.
F
Target gene provides figures to visualize the analysis results.
F indicates that this gene has visualization results on at least one type of sequencing data.