Overview of MCV Mutation, Integration-Cistrome Factor Overlap and Target gene

Merkel Cell Polyomavirus (MCV) was first described in January 2008 in Pittsburgh, Pennsylvania. It was the first example of a human viral pathogen discovered using unbiased metagenomic next-generation sequencing with a technique called digital transcriptome subtraction. MCV is one of seven currently known human oncoviruses. It is suspected to cause the majority of cases of Merkel cell carcinoma, a rare but aggressive form of skin cancer.
Size: 5.4kb
Encoding: Large T, Small T, VP1, VP2, etc.
Human Disease: Carcinoma, merkel cell, etc.
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MCV Mutation Info

Click here to see all MCV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	29696010	A20S	Small T	MCPyV_gp4	Carcinoma, merkel cell	L	View
2	29696010	L114P	Small T	MCPyV_gp4	Carcinoma, merkel cell	L	View
3	29696010	L142A	Small T	MCPyV_gp4	Carcinoma, merkel cell	L	View
4	21841310	R7A	Small T	MCPyV_gp4	Carcinoma, merkel cell Cell line	L T	View
5	21841310	L142A	Small T	MCPyV_gp4	Carcinoma, merkel cell Cell line	L T	View
6	21841310	D44N	Small T	MCPyV_gp4	Carcinoma, merkel cell Cell line	L T	View
7	34761184	D44N	Large T	MCPyV_gp3	Cell line	T	View
8	34761184	E216K	Large T	MCPyV_gp3	Cell line	T	View
9	35336880	C44A	Large T	MCPyV_gp3	Cell line	R T	View
10	35336880	S147A	Large T	MCPyV_gp3	Cell line	R T	View
11	35336880	W209A	Large T	MCPyV_gp3	Cell line	R T	View
12	36574443	D44N	Small T	MCPyV_gp4	Cell line	R T	View
13	36574443	R7A	Small T	MCPyV_gp4	Cell line	R T	View
14	36574443	L142A	Small T	MCPyV_gp4	Cell line	R T	View
15	39110744	R102A	Small T	MCPyV_gp4	Cell line	I T	View
16	25631078	C109S	Small T	MCPyV_gp4	Cell line	R T	View
17	25631078	I122A	Small T	MCPyV_gp4	Cell line	R T	View
18	25631078	L126A	Small T	MCPyV_gp4	Cell line	R T	View
19	25631078	H130A	Small T	MCPyV_gp4	Cell line	R T	View
20	25631078	E146A	Small T	MCPyV_gp4	Cell line	R T	View
21	25631078	Y150A	Small T	MCPyV_gp4	Cell line	R T	View
22	25631078	K134A	Small T	MCPyV_gp4	Cell line	R T	View
23	25631078	R7A	Small T	MCPyV_gp4	Cell line	R T	View
24	25631078	K118A	Small T	MCPyV_gp4	Cell line	R T	View
25	25631078	L133A	Small T	MCPyV_gp4	Cell line	R T	View
26	25631078	L142A	Small T	MCPyV_gp4	Cell line	R T	View
27	23990782	M129L	VP2	MCPyV_gp1	Cell line	R	View
28	23990782	M46A	VP2	MCPyV_gp1	Cell line	R	View
29	23990782	M46D	VP2	MCPyV_gp1	Cell line	R	View
30	23990782	M46I	VP2	MCPyV_gp1	Cell line	R	View
31	23990782	M46N	VP2	MCPyV_gp1	Cell line	R	View
32	23990782	M46V	VP2	MCPyV_gp1	Cell line	R	View
33	23954152	L142A	Small T	MCPyV_gp4	Cell line	T	View
34	21454559	T205A	Large T	MCPyV_gp3	Cell line	T	View
35	21454559	G207A	Large T	MCPyV_gp3	Cell line	T	View
36	21454559	T208A	Large T	MCPyV_gp3	Cell line	T	View
37	21454559	E216K	Large T	MCPyV_gp3	Cell line	T	View
38	21454559	R204A	Large T	MCPyV_gp3	Cell line	T	View
39	21454559	W209A	Large T	MCPyV_gp3	Cell line	T	View
40	21454559	Y206A	Large T	MCPyV_gp3	Cell line	T	View
41	32962090	S220A	Large T	MCPyV_gp3	Cell line	R	View
42	32962090	S239A	Large T	MCPyV_gp3	Cell line	R	View
43	32962090	S147A	Large T	MCPyV_gp3	Cell line	R	View
44	32962090	S142A	Large T	MCPyV_gp3	Cell line	R	View
45	28461484	S220A	Large T	MCPyV_gp3		R T	View
46	28461484	S239A	Large T	MCPyV_gp3		R T	View
47	28461484	S147A	Large T	MCPyV_gp3		R T	View
48	22910713	W76A	VP1	MCPyV_gp2		R	View
49	22910713	K295A	VP1	MCPyV_gp2		R	View
50	22910713	S297N	VP1	MCPyV_gp2		R	View
51	22910713	Y81V	VP1	MCPyV_gp2		R	View
52	21501625	F391A	Large T	MCPyV_gp3		R	View
53	21501625	F391R	Large T	MCPyV_gp3		R	View
54	21501625	K331A	Large T	MCPyV_gp3		R	View
55	21501625	K331R	Large T	MCPyV_gp3		R	View

Contents
Description

The table shows all curated mutation sites of MCV in each literature

Table Description Column Note

D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.

G
The study mentioned the virus genotype/subtype information.

R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.

S
The study provided sequence information or accession numbers.

L
The study provided the geographic region/country of data origin.

C
The study provided clinical baseline information.

I
The study involved information related to immune.

T
The study involved host target genes.

MCV Overlap Info between Viral Integration Fragments and Cistrome Factors

Click here to see all MCV Integration Sites

DVID	Chromosome	Histone Modification	Transcription Factor Binding Site	Chromatin Accessibility	Sum of Overlapped Records	Detail
7000040	chr1	6918	6167	2000	15085	View
7000001	chr1	551	1257	85	1893	View
7000050	chr1	22	67	36	125	View
7000010	chr1	41	7	0	48	View
7000013	chr1	20	1	3	24	View
7000024	chr1	20	1	3	24	View
7000058	chr1	0	5	0	5	View

Click to see histogram of VIS-Factor Overlap by chromosome of MCV

Click to see the overlap count of three factors and MCV intergration fragments on the human chromosomes

MCV Target Gene Info

Only show 100 info Click here to see all MCV Target Gene

ID	Target gene	Virus	Impact	Literature Count	Description	Detail
1	ADAMTS9	MCV	I	1	S C	View
2	AKT1	MCV	M	1	S C	View
3	BCL2L1	MCV	I	1	S C	View
4	BEST3	MCV	I	1	S C	View
5	BRD9	MCV	M	1	S C	View
6	BTRC	MCV	M	2	C	View
7	CAMK2A	MCV	I	1	C	View
8	CASZ1	MCV	I	2	S C	View
9	CBFA2T2	MCV	I	1	S C	View
10	CCNE1	MCV	M	1	S C	View
11	CDKAL1	MCV	I	2	S C	View
12	CREBBP	MCV	M	1	S C	View
13	CUX1	MCV	M	1	S C	View
14	DACH1	MCV	I	1	S C	View
15	DCAF7	MCV	I	1	S C	View
16	DICER1	MCV	M	1	S C	View
17	ECH1	MCV	I	1	S C	View
18	EIF4EBP1	MCV	M	1	S C	View
19	EIF4EBP2	MCV	M	1	S C	View
20	FBXW7	MCV	M	3	S C	View
21	FRG1	MCV	I	1	S	View
22	HSPA8	MCV	M	1	S C	View
23	IFNAR1	MCV	M	1	S C	View
24	INPP5E	MCV	I	1	C	View
25	IRF9	MCV	M	1	S C	View
26	JUN	MCV	M	1	S C	View
27	KMT2D	MCV	I	1	S C	View
28	LINC01994	MCV	I	1	C	View
29	LUTZP2	MCV	I	1		View
30	LUZP2	MCV	I	1	C	View
31	MTOR	MCV	M	1	S C	View
32	MYC	MCV	M	1	S C	View
33	OFCC1	MCV	I	1	C	View
34	PTP4A2	MCV	I	1	S C	View
35	PTPA	MCV	M	1	C	View
36	PTPRG	MCV	I	1	S C	View
37	RPS6KB1	MCV	M	1	S C	View
38	SF3B1	MCV	I	2	S C	View
39	SKP2	MCV	M	2	S C	View
40	TTC9C	MCV	I	1	S C	View
41	VPS39	MCV	M	2	S C	View

Contents Description and
Data Download

Table Note

I
Target gene is affected by virus integration.

M
Target gene is associated with the virus gene/protein/region.

E
Target gene is detected in the expression profiling data.

S
Target gene is detected in the single-cell transcriptome data.

C
Target gene is detected in the genome binding/occupancy profiling data.

M
Target gene is detected in the methylation profiling data.

F
Target gene provides figures to visualize the analysis results.
F indicates that this gene has visualization results on at least one type of sequencing data.