Overview of IV Mutation, Integration-Cistrome Factor Overlap and Target gene

Influenza Virus (IV) virion is pleomorphic; the viral envelope can occur in spherical and filamentous forms. There are four genera of influenza virus, each containing only a single species, or type. Influenza A and C infect a variety of species (including humans), while influenza B almost exclusively infects humans, and influenza D infects cattle and pigs.
Size: A:13.5kb;B:14.6kb;C:12.9kb;D:12.9-13.3kb
Encoding: HA1, HA2, M1, M2, NA, NP, NS1, NS2, PA, PB1, PB2, etc.
Human Disease: Influenza A, Influenza B, etc.
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IV Mutation Info

Click here to see all IV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	34141489	H274Y	NA	NA	Influenza A	D G	View
2	32161172	K206R	PA	PA	Influenza A	G S	View
3	24576826	K261E	NA	NA	Influenza A	D G S C L	View
4	32459617	K171N	HA	HA	Influenza A	G R L	View
5	32459617	K83E	HA	HA	Influenza A	G R L	View
6	32459617	K92R	HA	HA	Influenza A	G R L	View
7	32459617	P194L	HA	HA	Influenza A	G R L	View
8	32459617	P289S	HA	HA	Influenza A	G R L	View
9	32459617	R261Q	HA	HA	Influenza A	G R L	View
10	32459617	R33Q	HA	HA	Influenza A	G R L	View
11	32459617	S198P	HA	HA	Influenza A	G R L	View
12	32459617	T128A	HA	HA	Influenza A	G R L	View
13	32459617	T131K	HA	HA	Influenza A	G R L	View
14	24576826	K460R	NA	NA	Influenza A	D G S C L	View
15	32459617	T135K	HA	HA	Influenza A	G R L	View
16	32459617	V43I	HA	HA	Influenza A	G R L	View
17	32459617	V77I	HA	HA	Influenza A	G R L	View
18	31719554	A304T	HA	HA	Influenza A	G	View
19	31719554	N122D	HA	HA	Influenza A	G	View
20	31719554	N144E	HA	HA	Influenza A	G	View
21	31719554	N246K	HA	HA	Influenza A	G	View
22	31917822	F332L	HA	HA	Influenza A	G R	View
23	31917822	A144T	HA	HA	Influenza A	G R	View
24	31917822	T183A	HA	HA	Influenza A	G R	View
25	24576826	N322T	NA	NA	Influenza A	D G S C L	View
26	31917822	F209S	HA	HA	Influenza A	G R	View
27	31917822	N262T	HA	HA	Influenza A	G R	View
28	31917822	K18Q	HA	HA	Influenza A	G R	View
29	31917822	N160D	HA	HA	Influenza A	G R	View
30	34070388	T144A	HA	HA	Influenza A	G R C L	View
31	34070388	T144I	HA	HA	Influenza A	G R C L	View
32	34070388	T151K	HA	HA	Influenza A	G R C L	View
33	34070388	Q213R	HA	HA	Influenza A	G R C L	View
34	34070388	S214P	HA	HA	Influenza A	G R C L	View
35	34070388	T176K	HA	HA	Influenza A	G R C L	View
36	24576826	N341D	NA	NA	Influenza A	D G S C L	View
37	34070388	D69N	HA	HA	Influenza A	G R C L	View
38	34070388	Q277R	HA	HA	Influenza A	G R C L	View
39	34070388	N137K	HA	HA	Influenza A	G R C L	View
40	34070388	N187K	HA	HA	Influenza A	G R C L	View
41	34070388	E78K	HA	HA	Influenza A	G R C L	View
42	34070388	E78G	HA	HA	Influenza A	G R C L	View
43	39459850	N160S	HA	HA	Influenza A	G L	View
44	39459850	N189K	HA	HA	Influenza A	G L	View
45	24667168	G186V	HA1	HA	Influenza A	G R L	View
46	24667168	H156Q	HA1	HA	Influenza A	G R L	View
47	24576826	V236I	NA	NA	Influenza A	D G S C L	View
48	24667168	S219Y	HA1	HA	Influenza A	G R L	View
49	24667168	A186T	HA1	HA	Influenza A	G R L	View
50	24667168	S185P	HA1	HA	Influenza A	G R L	View
51	24667168	S185T	HA1	HA	Influenza A	G R L	View
52	24667168	A141T	HA1	HA	Influenza A	G R L	View
53	24667168	R205K	HA1	HA	Influenza A	G R L	View
54	24667168	S203T	HA1	HA	Influenza A	G R L	View
55	39443295	D32E			Influenza A	G R L	View
56	39443295	D513E			Influenza A	G R L	View
57	39443295	D7N			Influenza A	G R L	View
58	24951824	R292K	NA	NA	Influenza A	D G L	View
59	39443295	E50K			Influenza A	G R L	View
60	39443295	G53N			Influenza A	G R L	View
61	39443295	I140K			Influenza A	G R L	View
62	39443295	I140M			Influenza A	G R L	View
63	39443295	I192F			Influenza A	G R L	View
64	39443295	I223V			Influenza A	G R L	View
65	39443295	N378S			Influenza A	G R L	View
66	39443295	N96S			Influenza A	G R L	View
67	20702632	E627K			Influenza A	G S L	View
68	24153120	C153T			Influenza A	G S L	View
69	25124927	E119V	NA	NA	Influenza A	D G R L	View
70	24153120	C163T			Influenza A	G S L	View
71	24153120	G189T			Influenza A	G S L	View
72	26071346	E119V			Influenza A	D G S C L	View
73	26071346	R292K			Influenza A	D G S C L	View
74	29278832	K92R			Influenza A	G L	View
75	29278832	N121K			Influenza A	G L	View
76	29278832	R150K			Influenza A	G L	View
77	29278832	T135K			Influenza A	G L	View
78	21364825	G228S	HA	HA	Influenza A	G	View
79	21364825	Q226L	HA	HA	Influenza A	G	View
80	25124927	I222K	NA	NA	Influenza A	D G R L	View
81	30700609	N139K	HA	HA	Influenza A	G R I L	View
82	30700609	T128D	HA	HA	Influenza A	G R I L	View
83	23019374	S315N	NA	NA	Influenza A	G R L	View
84	33418392	R342V	HA	HA	Influenza A	G R	View
85	23019374	D225G	HA	HA	Influenza A	G R L	View
86	23437766	S31N	M2	M	Influenza A	D G	View
87	27630240	H274Y	HA	HA	Influenza A	G R L	View
88	28252002	K699R	PB2	PB2	Influenza A	G L	View
89	23436652	K339T	PB2	PB2	Influenza A	G R L	View
90	16516984	S31I	M2	M	Influenza A	D G L	View
91	25124927	I222R	NA	NA	Influenza A	D G R L	View
92	16516984	S31N	M2	M	Influenza A	D G L	View
93	16516984	V27A	M2	M	Influenza A	D G L	View
94	39557155	E23X	PA	PA	Influenza A	D G C L	View
95	19889895	S31N	M2	M	Influenza A	D G L	View
96	27203354	S31N	M2	M	Influenza A	D G R L	View
97	31223581	S31N	M2	M	Influenza A	D G S L	View
98	21917953	Y98F	HA	HA	Influenza A	G L	View
99	28385598	H259Y			Influenza A	D G L	View
100	25701593	E119K	NA	NA	Influenza A	D G S L	View

Contents
Description

The table shows all curated mutation sites of IV in each literature

Table Description Column Note

D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.

G
The study mentioned the virus genotype/subtype information.

R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.

S
The study provided sequence information or accession numbers.

L
The study provided the geographic region/country of data origin.

C
The study provided clinical baseline information.

I
The study involved information related to immune.

T
The study involved host target genes.

IV Target Gene Info

Only show 100 info Click here to see all IV Target Gene

ID	Target gene	Virus	Impact	Literature Count	Description	Detail
1	AGO2	IV	M	1	E S C	View
2	ANP32A	IV	M	1	E S C	View
3	CD8A	IV	M	1	E S C	View
4	CDK9	IV	M	1	E S C	View
5	CPSF4	IV	M	2	E C	View
6	IFNB1	IV	M	3	E C	View
7	KPNA2	IV	M	1	E S C	View
8	KPNA4	IV	M	1	E S C	View
9	KPNA6	IV	M	1	E S C	View
10	MX1	IV	M	1	E S C	View
11	PIK3CA	IV	M	1	E C	View
12	TARBP2	IV	M	1	E C	View
13	TRIM21	IV	M	1	E S C	View
14	TRIM25	IV	M	1	E S C	View

Contents Description and
Data Download

Table Note

I
Target gene is affected by virus integration.

M
Target gene is associated with the virus gene/protein/region.

E
Target gene is detected in the expression profiling data.

S
Target gene is detected in the single-cell transcriptome data.

C
Target gene is detected in the genome binding/occupancy profiling data.

M
Target gene is detected in the methylation profiling data.

F
Target gene provides figures to visualize the analysis results.
F indicates that this gene has visualization results on at least one type of sequencing data.