Overview of HEV Mutation, Integration-Cistrome Factor Overlap and Target gene

Hepatitis E Virus (HEV) is the causative agent of hepatitis E. Globally, approximately 939 million corresponding to 1 in 8 individuals have ever experienced HEV infection. About 15–110 million individuals have recent or ongoing HEV infection. The virus particle was first seen in 1983, but was only molecularly cloned in 1989.
Size: 7.2kb
Encoding: ORF1, ORF2, ORF3, RdRp, etc.
Human Disease: Acute Viral Hepatitis, Liver Failure, Acute, Chronic Hepatitis E, etc.
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HEV Mutation Info

Click here to see all HEV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	19402955	I978V	ORF1	ORF1	Severe Hepatitis	G R S C L	View
2	19402955	S605P	ORF1	ORF1	Severe Hepatitis	G R S C L	View
3	19402955	V1213A	ORF1	ORF1	Severe Hepatitis	G R S C L	View
4	19402955	V239A	ORF1	ORF1	Severe Hepatitis	G R S C L	View
5	27320795	C1483W	RdRp	ORF1	Liver Failure, Acute Acute Viral Hepatitis	G R S C L	View
6	27320795	N1530T	RdRp	ORF1	Liver Failure, Acute Acute Viral Hepatitis	G R S C L	View
7	28359977	A341G	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
8	28359977	C238T	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
9	28359977	C267T	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
10	28359977	C385T	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
11	28359977	D29N	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
12	28359977	337delC	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
13	28359977	G115A	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
14	28359977	G30A	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
15	28359977	G86A	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
16	28359977	H105R	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
17	28359977	T107C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
18	28359977	T200C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
19	28359977	T222C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
20	28359977	T285C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
21	28359977	T288C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
22	28359977	T321C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
23	28359977	T390A	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
24	28359977	T414C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
25	28359977	T441C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
26	28359977	T78C	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
27	28359977	V27A	Methyltransferase	ORF1	Liver Failure, Acute	G R S C L	View
28	25100237	C5933T	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
29	25100237	C6032T	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
30	25100237	C6104T	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
31	25100237	F356L	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
32	25100237	G6098A	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
33	25100237	K350E	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
34	25100237	P259S	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
35	25100237	T6014C	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
36	25100237	6209delT	ORF2	ORF2	Liver Failure, Acute	G R S C L	View
37	24630891	L1110F	ORF1	ORF1	Liver Failure, Acute	G R	View
38	24630891	V1120I	ORF1	ORF1	Liver Failure, Acute	G R	View
39	27222534	D1384G	RdRp	ORF1	Liver Cirrhosis Liver Failure	D G R C L	View
40	27222534	G1634R	RdRp	ORF1	Liver Cirrhosis Liver Failure	D G R C L	View
41	27222534	K1383N	RdRp	ORF1	Liver Cirrhosis Liver Failure	D G R C L	View
42	27222534	V1479I	RdRp	ORF1	Liver Cirrhosis Liver Failure	D G R C L	View
43	27222534	Y1587F	RdRp	ORF1	Liver Cirrhosis Liver Failure	D G R C L	View
44	37984761	G1634R	RdRp	ORF1	HEV Infection Cell line	D G R	View
45	37984761	Y1320H	RdRp	ORF1	HEV Infection Cell line	D G R	View
46	39377575	V711A	HVR	ORF2	HEV Infection	G R	View
47	39377575	V711D	HVR	ORF2	HEV Infection	G R	View
48	39377575	V711S	HVR	ORF2	HEV Infection	G R	View
49	39377575	S711A	HVR	ORF2	HEV Infection	G R	View
50	39377575	S711D	HVR	ORF2	HEV Infection	G R	View
51	39377575	S708A	HVR	ORF2	HEV Infection	G R	View
52	39377575	S708D	HVR	ORF2	HEV Infection	G R	View
53	39377575	S712A	HVR	ORF2	HEV Infection	G R	View
54	39377575	S712D	HVR	ORF2	HEV Infection	G R	View
55	39377575	S715A	HVR	ORF2	HEV Infection	G R	View
56	39377575	S715D	HVR	ORF2	HEV Infection	G R	View
57	38242291	F204L	RdRp	ORF1	HEV Infection	G R S L	View
58	38242291	L238F	RdRp	ORF1	HEV Infection	G R S L	View
59	36942308	D1384G	RdRp	ORF1	HEV Infection	D G C	View
60	36942308	G1634R	RdRp	ORF1	HEV Infection	D G C	View
61	36942308	K1383N	RdRp	ORF1	HEV Infection	D G C	View
62	36942308	V1305I	RdRp	ORF1	HEV Infection	G C	View
63	40132339	N1432Y	ORF1	ORF1	HEV Infection	G R C L	View
64	40132339	P1431S	ORF1	ORF1	HEV Infection	G R C L	View
65	40132339	S1453P	ORF1	ORF1	HEV Infection	G R C L	View
66	40132339	V1479I	ORF1	ORF1	HEV Infection	D G R C L	View
67	40132339	E435D	ORF2	ORF2	HEV Infection	G R C L	View
68	40132339	G490N	ORF2	ORF2	HEV Infection	G R C L	View
69	40132339	L500F	ORF2	ORF2	HEV Infection	G R C L	View
70	40132339	S483T	ORF2	ORF2	HEV Infection	G R C L	View
71	40132339	S497T	ORF2	ORF2	HEV Infection	G R C L	View
72	40132339	S527T	ORF2	ORF2	HEV Infection	G R C L	View
73	40132339	T517S	ORF2	ORF2	HEV Infection	G R C L	View
74	40132339	T529I	ORF2	ORF2	HEV Infection	G R C L	View
75	40132339	V492M	ORF2	ORF2	HEV Infection	G R C L	View
76	19393700	7189del	3'UTR		HEV Infection	G R L	View
77	25916609	V239A	Helicase	ORF1	HEV Infection	G R S L	View
78	19393700	C5145T	ORF3	ORF3	HEV Infection	G R L	View
79	34293039	A317T	ORF1	ORF1	HEV Infection	G R S L	View
80	34293039	G1634K	ORF1	ORF1	HEV Infection	D G R S L	View
81	34293039	L1110F	ORF1	ORF1	HEV Infection	G R S L	View
82	34293039	L1120I	ORF1	ORF1	HEV Infection	G R S L	View
83	34293039	P259S	ORF2	ORF2	HEV Infection	G R S L	View
84	34293039	T735I	ORF1	ORF1	HEV Infection	G R S L	View
85	34293039	V1120I	ORF1	ORF1	HEV Infection	G R S L	View
86	34293039	V1479I	ORF1	ORF1	HEV Infection	D G R S L	View
87	33877740	P76L	ORF2	ORF2	HEV Infection	G R I C L	View
88	33877740	S68L	ORF2	ORF2	HEV Infection	G R C L	View
89	34293039	L477T	ORF2	ORF2	HEV Infection	G R S I L	View
90	34293039	L613T	ORF2	ORF2	HEV Infection	G R S I L	View
91	33877740	A88N	ORF3	ORF3	HEV Infection	G R C L	View
92	33877740	A88V	ORF3	ORF3	HEV Infection	G R C L	View
93	33877740	D90G	ORF3	ORF3	HEV Infection	G R C L	View
94	33877740	H81C	ORF3	ORF3	HEV Infection	G R I C L	View
95	33877740	L87P	ORF3	ORF3	HEV Infection	G R C L	View
96	33877740	N82I	ORF3	ORF3	HEV Infection	G R C L	View
97	33877740	P77L	ORF3	ORF3	HEV Infection	G R C L	View
98	33877740	R92Q	ORF3	ORF3	HEV Infection	G R C L	View
99	33877740	S79L	ORF3	ORF3	HEV Infection	G R I C L	View
100	33877740	Y80T	ORF3	ORF3	HEV Infection	G R C L	View

Contents
Description

The table shows all curated mutation sites of HEV in each literature

Table Description Column Note

D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.

G
The study mentioned the virus genotype/subtype information.

R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.

S
The study provided sequence information or accession numbers.

L
The study provided the geographic region/country of data origin.

C
The study provided clinical baseline information.

I
The study involved information related to immune.

T
The study involved host target genes.

HEV Target Gene Info

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ID	Target gene	Virus	Impact	Literature Count	Description	Detail
1	ANXA2	HEV	M	1	E	View
2	CD63	HEV	M	1	E	View
3	CD9	HEV	M	1	E	View
4	EIF2S1	HEV	M	1	E	View
5	PRMT5	HEV	M	1	E	View
6	WDR77	HEV	M	1	E	View

Contents Description and
Data Download

Table Note

I
Target gene is affected by virus integration.

M
Target gene is associated with the virus gene/protein/region.

E
Target gene is detected in the expression profiling data.

S
Target gene is detected in the single-cell transcriptome data.

C
Target gene is detected in the genome binding/occupancy profiling data.

M
Target gene is detected in the methylation profiling data.

F
Target gene provides figures to visualize the analysis results.
F indicates that this gene has visualization results on at least one type of sequencing data.