Overview of HCV Mutation, Integration-Cistrome Factor Overlap and Target gene

Hepatitis C Virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma, abbreviated HCC) and lymphomas in humans.
Size: 9.6kb
Encoding: 5'UTR, C, E1, E2, NS2, NS3, NS4B, NS5A, NS5B, p7, Protease, etc.
Human Disease: Hepatitis C, Chronic, Liver Cirrhosis, Carcinoma, Hepatocellular, etc.
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HCV Mutation Info
Only show 100 info Click here to see all HCV Mutation Sites
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 19088272 D535A
E2
E2
Carcinoma, Hepatocellular
T
View
2 20175782 G435C
C
Core
Carcinoma, Hepatocellular
G
View
3 24625789 K1998R
NS5A
NS5A
Cell line
View
4 23095680 H110N
NS3
NS3
HCV Infection
R
View
5 23095680 H69R
NS3
NS3
HCV Infection
R
View
6 23095680 I114V
NS3
NS3
HCV Infection
R
View
7 23095680 I132M
NS3
NS3
HCV Infection
R
View
8 23095680 I132V
NS3
NS3
HCV Infection
R
View
9 23095680 I153L
NS3
NS3
HCV Infection
R
View
10 23095680 I153V
NS3
NS3
HCV Infection
R
View
11 23095680 I170V
NS3
NS3
HCV Infection
R
View
12 23095680 I18V
NS3
NS3
HCV Infection
R
View
13 23095680 I48V
NS3
NS3
HCV Infection
R
View
14 24625789 K2050R
NS5A
NS5A
Cell line
View
15 23095680 I64L
NS3
NS3
HCV Infection
R
View
16 23095680 I71L
NS3
NS3
HCV Infection
R
View
17 23095680 K26R
NS3
NS3
HCV Infection
R
View
18 23095680 K61R
NS3
NS3
HCV Infection
R
View
19 23095680 L127I
NS3
NS3
HCV Infection
R
View
20 23095680 L132I
NS3
NS3
HCV Infection
R
View
21 23095680 L13M
NS3
NS3
HCV Infection
R
View
22 23095680 L13W
NS3
NS3
HCV Infection
R
View
23 23095680 L14F
NS3
NS3
HCV Infection
R
View
24 23095680 L44M
NS3
NS3
HCV Infection
R
View
25 24625789 K2277R
NS5A
NS5A
Cell line
View
26 23095680 L72F
NS3
NS3
HCV Infection
R
View
27 23095680 L82G
NS3
NS3
HCV Infection
R
View
28 23095680 M147L
NS3
NS3
HCV Infection
R
View
29 23095680 M147Q
NS3
NS3
HCV Infection
R
View
30 23095680 N174G
NS3
NS3
HCV Infection
R
View
31 23095680 N174S
NS3
NS3
HCV Infection
R
View
32 23095680 N49S
NS3
NS3
HCV Infection
R
View
33 23095680 N72C
NS3
NS3
HCV Infection
R
View
34 23095680 P146S
NS3
NS3
HCV Infection
R
View
35 23095680 P86S
NS3
NS3
HCV Infection
R
View
36 24625789 K2280D
NS5A
NS5A
Cell line
View
37 23095680 Q28E
NS3
NS3
HCV Infection
R
View
38 23095680 Q28L
NS3
NS3
HCV Infection
R
View
39 23095680 R117C
NS3
NS3
HCV Infection
R
View
40 23095680 R117H
NS3
NS3
HCV Infection
R
View
41 23095680 R119Q
NS3
NS3
HCV Infection
R
View
42 23095680 R11P
NS3
NS3
HCV Infection
R
View
43 23095680 R123K
NS3
NS3
HCV Infection
R
View
44 23095680 R150A
NS3
NS3
HCV Infection
R
View
45 23095680 R150V
NS3
NS3
HCV Infection
R
View
46 23095680 R24K
NS3
NS3
HCV Infection
R
View
47 24625789 L2003F
NS5A
NS5A
Cell line
View
48 23095680 R92K
NS3
NS3
HCV Infection
R
View
49 23095680 R92T
NS3
NS3
HCV Infection
R
View
50 23095680 S101A
NS3
NS3
HCV Infection
R
View
51 23095680 S102A
NS3
NS3
HCV Infection
R
View
52 23095680 S122G
NS3
NS3
HCV Infection
R
View
53 23095680 S122T
NS3
NS3
HCV Infection
R
View
54 23095680 S134T
NS3
NS3
HCV Infection
R
View
55 23095680 S147L
NS3
NS3
HCV Infection
R
View
56 23095680 S15G
NS3
NS3
HCV Infection
R
View
57 23095680 S166A
NS3
NS3
HCV Infection
R
View
58 24625789 L2347R
NS5A
NS5A
Cell line
View
59 23095680 S174A
NS3
NS3
HCV Infection
R
View
60 23095680 S174L
NS3
NS3
HCV Infection
R
View
61 23095680 S174T
NS3
NS3
HCV Infection
R
View
62 23095680 S20G
NS3
NS3
HCV Infection
R
View
63 23095680 S42F
NS3
NS3
HCV Infection
R
View
64 23095680 S42T
NS3
NS3
HCV Infection
R
View
65 23095680 S60A
NS3
NS3
HCV Infection
R
View
66 23095680 S60T
NS3
NS3
HCV Infection
R
View
67 23095680 S65C
NS3
NS3
HCV Infection
R
View
68 23095680 S67A
NS3
NS3
HCV Infection
R
View
69 24625789 P2369H
NS5A
NS5A
Cell line
View
70 23095680 S67P
NS3
NS3
HCV Infection
R
View
71 23095680 S91A
NS3
NS3
HCV Infection
R
View
72 23095680 S91T
NS3
NS3
HCV Infection
R
View
73 23095680 T10H
NS3
NS3
HCV Infection
R
View
74 23095680 T10N
NS3
NS3
HCV Infection
R
View
75 23095680 T122S
NS3
NS3
HCV Infection
R
View
76 23095680 T46A
NS3
NS3
HCV Infection
R
View
77 23095680 T46S
NS3
NS3
HCV Infection
R
View
78 23095680 T61S
NS3
NS3
HCV Infection
R
View
79 23095680 T72A
NS3
NS3
HCV Infection
R
View
80 24625789 R1978K
NS5A
NS5A
Cell line
View
81 23095680 T95E
NS3
NS3
HCV Infection
R
View
82 23095680 T95S
NS3
NS3
HCV Infection
R
View
83 23095680 V107I
NS3
NS3
HCV Infection
R
View
84 23095680 V114I
NS3
NS3
HCV Infection
R
View
85 23095680 V150A
NS3
NS3
HCV Infection
R
View
86 23095680 V177I
NS3
NS3
HCV Infection
R
View
87 23095680 V18I
NS3
NS3
HCV Infection
R
View
88 23095680 V28I
NS3
NS3
HCV Infection
R
View
89 23095680 V28M
NS3
NS3
HCV Infection
R
View
90 23095680 V33I
NS3
NS3
HCV Infection
R
View
91 24625789 S2079Y
NS5A
NS5A
Cell line
View
92 23095680 V35I
NS3
NS3
HCV Infection
R
View
93 23095680 V48I
NS3
NS3
HCV Infection
R
View
94 23095680 V48L
NS3
NS3
HCV Infection
R
View
95 23095680 V51A
NS3
NS3
HCV Infection
R
View
96 23095680 V51T
NS3
NS3
HCV Infection
R
View
97 23095680 V83N
NS3
NS3
HCV Infection
R
View
98 23095680 V83T
NS3
NS3
HCV Infection
R
View
99 23095680 Y105F
NS3
NS3
HCV Infection
R
View
100 23095680 Y56C
NS3
NS3
HCV Infection
R
View
Contents
Description

The table shows all curated mutation sites of HCV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.


HCV Target Gene Info
Only show 100 info Click here to see all HCV Target Gene
ID Target gene Virus Impact Literature Count Description Detail
1 CD81 HCV
M
1
E
C
M
View
2 IFNL3 HCV
M
3
E
C
View
3 MIR122 HCV
M
1
E
C
View
4 PPIB HCV
M
1
E
C
View
Contents Description and
Data Download
Table Note
I
Target gene is affected by virus integration.
M
Target gene is associated with the virus gene/protein/region.
E
Target gene is detected in the expression profiling data.
S
Target gene is detected in the single-cell transcriptome data.
C
Target gene is detected in the genome binding/occupancy profiling data.
M
Target gene is detected in the methylation profiling data.
F
Target gene provides figures to visualize the analysis results.
F indicates that this gene has visualization results on at least one type of sequencing data.