Gene Name	CD8A
Gene ID	925
Gene Full Name	CD8 subunit alpha
Gene Alias	CD8|CD8alpha|IMD116|Leu2|p32
Transcripts	ENSG00000153563
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Intracellular and membrane;
Membrane Info	CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P01732
HGNC ID	HGNC:1706
OMIM ID	186910
Summary	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	17559687	K103N	RT	gag-pol	HIV Infections	D G C L T	View
2	17559687	M184V	RT	gag-pol	HIV Infections	D G C L T	View
3	17559687	Y181C	RT	gag-pol	HIV Infections	D G C L T	View
4	24465210	A14L	Vpu	Vpu	HIV Infections	G R I C L T	View
5	24465210	A15T	Vpu	Vpu	HIV Infections	G R I C L T	View
6	24465210	A15V	Vpu	Vpu	HIV Infections	G R I C L T	View
7	24465210	A19E	Vpu	Vpu	HIV Infections	G R I C L T	View
8	24465210	A50T	Vpu	Vpu	HIV Infections	G R I C L T	View
9	24465210	A50V	Vpu	Vpu	HIV Infections	G R I C L T	View
10	24465210	D52V	Vpu	Vpu	HIV Infections	G R I C L T	View
11	24465210	E29K	Vpu	Vpu	HIV Infections	G R I C L T	View
12	24465210	E56G	Vpu	Vpu	HIV Infections	G R I C L T	View
13	24465210	E58K	Vpu	Vpu	HIV Infections	G R I C L T	View
14	24465210	E62G	Vpu	Vpu	HIV Infections	G R I C L T	View
15	24465210	G59R	Vpu	Vpu	HIV Infections	G R I C L T	View
16	24465210	I16E	Vpu	Vpu	HIV Infections	G R I C L T	View
17	24465210	I17T	Vpu	Vpu	HIV Infections	G R I C L T	View
18	24465210	I39L	Vpu	Vpu	HIV Infections	G R I C L T	View
19	24465210	I9M	Vpu	Vpu	HIV Infections	G R I C L T	View
20	24465210	N55H	Vpu	Vpu	HIV Infections	G R I C L T	View
21	24465210	S53N	Vpu	Vpu	HIV Infections	G R I C L T	View
22	24465210	V22A	Vpu	Vpu	HIV Infections	G R I C L T	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
E   GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
S   GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
S   GSE205320	scRNA-seq	5	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
S   GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
E   GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
S   GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
S   GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
S   GSE198809	scRNA-seq	46	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Expression profiling
• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE144332 - CD8A expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE162914 - CD8A expression across samples

Volcano Plot

Bar Plot