Gene Name	KDM2A
Gene ID	22992
Gene Full Name	lysine demethylase 2A
Gene Alias	CXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINA
Transcripts	ENSG00000173120
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;
Membrane Info	Enzymes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q9Y2K7
HGNC ID	HGNC:13606
OMIM ID	605657
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001813	chr11	106	22	2	130	View
4002161	chr11	105	4	0	109	View
4002261	chr11	101	1	0	102	View
4002414	chr11	92	3	0	95	View
4002626	chr11	81	5	0	86	View
4003107	chr11	7	4	58	69	View
4004399	chr11	40	5	0	45	View
4004794	chr11	37	2	0	39	View
4004836	chr11	28	11	0	39	View
4004944	chr11	34	2	1	37	View
4004988	chr11	35	1	1	37	View
4004998	chr11	36	1	0	37	View
4005733	chr11	29	1	0	30	View
4005850	chr11	28	1	0	29	View
4006982	chr11	20	1	0	21	View
4007017	chr11	20	1	0	21	View
4007376	chr11	18	1	0	19	View
4007483	chr11	18	1	0	19	View
4007492	chr11	16	2	1	19	View
4007962	chr11	12	5	0	17	View
4008131	chr11	10	5	1	16	View
4008660	chr11	12	2	0	14	View
4008897	chr11	0	13	0	13	View
4008916	chr11	5	5	3	13	View
4009520	chr11	8	3	0	11	View
4010175	chr11	9	0	0	9	View
4010271	chr11	8	1	0	9	View
4010545	chr11	8	0	0	8	View
4010546	chr11	5	3	0	8	View
4011126	chr11	6	1	0	7	View
4011872	chr11	4	2	0	6	View
4012049	chr11	4	1	0	5	View
4012389	chr11	3	2	0	5	View
4012437	chr11	4	1	0	5	View
4012862	chr11	4	0	0	4	View
4012863	chr11	4	0	0	4	View
4013969	chr11	2	1	0	3	View
4014336	chr11	2	0	0	2	View
4014827	chr11	1	1	0	2	View
4016168	chr11	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - KDM2A peak across samples

Peak Plot

> Dataset: GSE165705 - KDM2A peak across samples

Peak Plot

> Dataset: GSE30738 - KDM2A peak across samples

Peak Plot

> Dataset: GSE144329 - KDM2A peak across samples

Peak Plot

> Dataset: GSE220859 - KDM2A peak across samples

Peak Plot

> Dataset: GSE211651 - KDM2A peak across samples

Peak Plot

> Dataset: GSE100376 - KDM2A peak across samples

Peak Plot

> Dataset: GSE100266 - KDM2A peak across samples

Peak Plot

> Dataset: GSE165703 - KDM2A peak across samples

Peak Plot