Gene Name	POLR2A
Gene ID	5430
Gene Full Name	RNA polymerase II subunit A
Gene Alias	NEDHIB|POLR2|POLRA|RPB1|RPBh1|RPO2|RPOL2|RpIILS|hRPB220|hsRPB1
Transcripts	ENSG00000181222
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
HGNC ID	HGNC:9187
OMIM ID	180660
Summary	This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000433	chr17	218	246	2	466	View
4001491	chr17	20	138	0	158	View
4005064	chr17	4	32	0	36	View
4005604	chr17	20	11	0	31	View
4005825	chr17	4	25	0	29	View
4006411	chr17	25	0	0	25	View
4009498	chr17	11	0	0	11	View
4009736	chr17	11	0	0	11	View
4010565	chr17	5	0	3	8	View
4010957	chr17	6	1	1	8	View
4011062	chr17	6	1	0	7	View
4012250	chr17	4	1	0	5	View
4013443	chr17	2	1	0	3	View
4013622	chr17	1	2	0	3	View
4013623	chr17	2	1	0	3	View
4015173	chr17	0	1	0	1	View
4015979	chr17	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE198809	scRNA-seq	46	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - POLR2A peak across samples

Peak Plot

> Dataset: GSE165705 - POLR2A peak across samples

Peak Plot

> Dataset: GSE144329 - POLR2A peak across samples

Peak Plot

> Dataset: GSE220859 - POLR2A peak across samples

Peak Plot

> Dataset: GSE211651 - POLR2A peak across samples

Peak Plot

> Dataset: GSE100376 - POLR2A peak across samples

Peak Plot

> Dataset: GSE100266 - POLR2A peak across samples

Peak Plot

> Dataset: GSE165703 - POLR2A peak across samples

Peak Plot