Gene Name	SETD2
Gene ID	29072
Gene Full Name	SET domain containing 2, histone lysine methyltransferase
Gene Alias	HBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|MRD70|RAPAS|SET2|p231HBP
Transcripts	ENSG00000181555
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Nuclear speckles;Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q9BYW2
HGNC ID	HGNC:18420
OMIM ID	612778
Summary	Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000696	chr3	296	9	9	314	View
4001278	chr3	132	19	33	184	View
4001841	chr3	26	35	66	127	View
4004523	chr3	36	7	0	43	View
4004536	chr3	27	8	8	43	View
4005571	chr3	31	0	0	31	View
4005572	chr3	9	10	12	31	View
4007521	chr3	6	13	0	19	View
4008352	chr3	8	3	4	15	View
4010595	chr3	8	0	0	8	View
4012033	chr3	4	1	0	5	View
4012487	chr3	5	0	0	5	View
4013812	chr3	1	2	0	3	View
4013911	chr3	1	2	0	3	View
4015110	chr3	1	0	0	1	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - SETD2 peak across samples

Peak Plot

> Dataset: GSE165705 - SETD2 peak across samples

Peak Plot

> Dataset: GSE30738 - SETD2 peak across samples

Peak Plot

> Dataset: GSE144329 - SETD2 peak across samples

Peak Plot

> Dataset: GSE220859 - SETD2 peak across samples

Peak Plot

> Dataset: GSE211651 - SETD2 peak across samples

Peak Plot

> Dataset: GSE100376 - SETD2 peak across samples

Peak Plot

> Dataset: GSE100266 - SETD2 peak across samples

Peak Plot

> Dataset: GSE165703 - SETD2 peak across samples

Peak Plot