HIV Target gene Detail Information

> DNMT1 Gene Search Result


Gene Information
Gene Name DNMT1
Gene ID 1786
Gene Full Name DNA methyltransferase 1
Gene Alias ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|m.HsaI
Transcripts ENSG00000130816
Virus HIV
Gene Type protein-coding
HPA Location Info Nucleoplasm;
Membrane Info Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID P26358
HGNC ID HGNC:2976
OMIM ID 126375
Summary This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Target gene [DNMT1] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000676 chr19 313 8 2 323 View
4003847 chr19 53 0 0 53 View
4004186 chr19 25 20 3 48 View
4004444 chr19 3 32 9 44 View
4005013 chr19 9 28 0 37 View
4005205 chr19 20 15 0 35 View
4005227 chr19 21 12 2 35 View
4005827 chr19 17 10 2 29 View
4005914 chr19 22 5 1 28 View
4006397 chr19 17 6 2 25 View
4007090 chr19 1 17 3 21 View
4007668 chr19 17 1 0 18 View
4008078 chr19 16 0 0 16 View
4009243 chr19 12 0 0 12 View
4011381 chr19 3 4 0 7 View
4012093 chr19 3 2 0 5 View
4012094 chr19 5 0 0 5 View
4012095 chr19 4 1 0 5 View
4012468 chr19 5 0 0 5 View
4012934 chr19 3 1 0 4 View
4013885 chr19 3 0 0 3 View

Target gene [DNMT1] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE221688 		Chip-seq;scATAC-Seq;scRNA-Seq 12 Illumina NovaSeq 6000 (Homo sapiens)
GSE99737 RNA-seq 9 Illumina HiSeq 2500 (Homo sapiens)
E
  GSE144332 		RNA-seq 75 NextSeq 550 (Homo sapiens)
GSE157829 scRNA-seq 7 Illumina HiSeq 2500 (Homo sapiens)
C
  GSE165705 		Chip-seq 30 Illumina NovaSeq 6000 (Homo sapiens)
GSE164264 RNA-seq 6 BGISEQ-500 (Homo sapiens)
GSE262621 RNA-seq 70 Illumina NovaSeq 6000 (Homo sapiens)
GSE202410 scRNA-seq 24 Illumina HiSeq 4000 (Homo sapiens)
GSE128121 RNA-seq 16 Illumina HiSeq 4000 (Homo sapiens)
GSE162914 RNA-seq 211 Illumina HiSeq 2500 (Homo sapiens)
GSE187515 scRNA-seq 104 Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982 Methylation profiling (Array) 576 Infinium MethylationEPIC
C
  GSE144329 		ATAC-seq 96 NextSeq 550 (Homo sapiens)
GSE205204 RNA-seq 14 Illumina NovaSeq 6000 (Homo sapiens)
GSE125686 RNA-seq 62 Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
S
  GSE198339 		scRNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
S
  GSE233747 		scRNA-seq 40 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE220859 		Chip-seq 11 Illumina NovaSeq 6000 (Homo sapiens)
GSE165708 RNA-seq 100 Illumina HiSeq 4000 (Homo sapiens)
C
  GSE211651 		Chip-seq;RNA-seq;PRO-seq 39 Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028 MeDIP-chip 1 NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C
  GSE100376 		ATAC-seq 24 Illumina NextSeq 500 (Homo sapiens)
GSE167211 RNA-seq 1 Illumina HiSeq 2000 (Homo sapiens)
GSE165132 RNA-seq 56 NextSeq 550 (Homo sapiens)
S
  GSE228078 		scRNA-seq 12 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE100266 		ATAC-seq;Chip-seq;RNA-seq 32 Illumina HiSeq 2500 (Homo sapiens)
C
  GSE165703 		ATAC-seq 82 Illumina HiSeq 4000 (Homo sapiens)
GSE148796 scRNA-seq 4 Illumina NextSeq 500 (Homo sapiens)
GSE246082 RNA-seq 6 Illumina HiSeq 4000 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE144332 - DNMT1 expression across samples

Volcano Plot

Bar Plot