HIV Target gene Detail Information

> LCK Gene Search Result


Gene Information
Gene Name LCK
Gene ID 3932
Gene Full Name LCK proto-oncogene, Src family tyrosine kinase
Gene Alias IMD22|LSK|YT16|p56lck|pp58lck
Transcripts ENSG00000182866
Virus HIV
Gene Type protein-coding
HPA Location Info Golgi apparatus;
Membrane Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins
Uniport_ID P06239
HGNC ID HGNC:6524
OMIM ID 153390
Summary This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]
Target gene [LCK] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000784 chr1 270 13 0 283 View
4001521 chr1 132 16 6 154 View
4002391 chr1 4 58 34 96 View
4003065 chr1 26 35 9 70 View
4007831 chr1 10 7 0 17 View
4007832 chr1 9 7 1 17 View
4011152 chr1 7 0 0 7 View
4014660 chr1 1 1 0 2 View

Target gene [LCK] related to Omics data
Data ID Experiment type Sample number Platform
GSE99737 RNA-seq 9 Illumina HiSeq 2500 (Homo sapiens)
E
  GSE144332 		RNA-seq 75 NextSeq 550 (Homo sapiens)
S
  GSE157829 		scRNA-seq 7 Illumina HiSeq 2500 (Homo sapiens)
S
  GSE205320 		scRNA-seq 5 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE165705 		Chip-seq 30 Illumina NovaSeq 6000 (Homo sapiens)
GSE164264 RNA-seq 6 BGISEQ-500 (Homo sapiens)
GSE262621 RNA-seq 70 Illumina NovaSeq 6000 (Homo sapiens)
S
  GSE202410 		scRNA-seq 24 Illumina HiSeq 4000 (Homo sapiens)
GSE128121 RNA-seq 16 Illumina HiSeq 4000 (Homo sapiens)
E
  GSE162914 		RNA-seq 211 Illumina HiSeq 2500 (Homo sapiens)
S
  GSE187515 		scRNA-seq 104 Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982 Methylation profiling (Array) 576 Infinium MethylationEPIC
C
  GSE144329 		ATAC-seq 96 NextSeq 550 (Homo sapiens)
GSE205204 RNA-seq 14 Illumina NovaSeq 6000 (Homo sapiens)
GSE125686 RNA-seq 62 Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
S
  GSE198339 		scRNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
S
  GSE233747 		scRNA-seq 40 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE220859 		Chip-seq 11 Illumina NovaSeq 6000 (Homo sapiens)
GSE165708 RNA-seq 100 Illumina HiSeq 4000 (Homo sapiens)
C
  GSE211651 		Chip-seq;RNA-seq;PRO-seq 39 Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
S
  GSE198809 		scRNA-seq 46 Illumina NovaSeq 6000 (Homo sapiens)
GSE68028 MeDIP-chip 1 NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
GSE167211 RNA-seq 1 Illumina HiSeq 2000 (Homo sapiens)
GSE165132 RNA-seq 56 NextSeq 550 (Homo sapiens)
S
  GSE228078 		scRNA-seq 12 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE100266 		ATAC-seq;Chip-seq;RNA-seq 32 Illumina HiSeq 2500 (Homo sapiens)
S
  GSE148796 		scRNA-seq 4 Illumina NextSeq 500 (Homo sapiens)
GSE246082 RNA-seq 6 Illumina HiSeq 4000 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE144332 - LCK expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE162914 - LCK expression across samples

Volcano Plot

Bar Plot