Gene Name	NSD1
Gene ID	64324
Gene Full Name	nuclear receptor binding SET domain protein 1
Gene Alias	ARA267|KMT3B|SOTOS|SOTOS1|STO
Transcripts	ENSG00000165671
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Plasma membrane;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q96L73
HGNC ID	HGNC:14234
OMIM ID	606681
Summary	This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Sep 2018]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000114	chr5	60	423	534	1017	View
4000115	chr5	58	422	534	1014	View
4000735	chr5	298	1	0	299	View
4002053	chr5	102	13	0	115	View
4003728	chr5	53	3	0	56	View
4004074	chr5	49	1	0	50	View
4004382	chr5	8	37	0	45	View
4005835	chr5	24	0	5	29	View
4006761	chr5	8	14	1	23	View
4007211	chr5	10	10	0	20	View
4007275	chr5	19	1	0	20	View
4007829	chr5	15	2	0	17	View
4008028	chr5	14	3	0	17	View
4008565	chr5	13	1	0	14	View
4008974	chr5	10	3	0	13	View
4009041	chr5	12	1	0	13	View
4010804	chr5	0	8	0	8	View
4011480	chr5	6	1	0	7	View
4011481	chr5	6	1	0	7	View
4012333	chr5	5	0	0	5	View
4012334	chr5	5	0	0	5	View
4016383	chr5	0	0	0	0	View
4016529	chr5	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE148796	scRNA-seq	4	Illumina NextSeq 500 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - NSD1 peak across samples

Peak Plot

> Dataset: GSE165705 - NSD1 peak across samples

Peak Plot

> Dataset: GSE30738 - NSD1 peak across samples

Peak Plot

> Dataset: GSE144329 - NSD1 peak across samples

Peak Plot

> Dataset: GSE220859 - NSD1 peak across samples

Peak Plot

> Dataset: GSE211651 - NSD1 peak across samples

Peak Plot

> Dataset: GSE100376 - NSD1 peak across samples

Peak Plot

> Dataset: GSE100266 - NSD1 peak across samples

Peak Plot

> Dataset: GSE165703 - NSD1 peak across samples

Peak Plot