Gene Name	MX2
Gene ID	4600
Gene Full Name	MX dynamin like GTPase 2
Gene Alias	MXB
Transcripts	ENSG00000183486
Virus	HIV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	P20592
HGNC ID	HGNC:7533
OMIM ID	147890
Summary	The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	32873191	A88T	Gag	Gag	Acquired Immunodeficiency Syndrome	D G T	View
2	32873191	I55N	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
3	32873191	L18T	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
4	32873191	L60R	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
5	32873191	P31A	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
6	32873191	P31H	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
7	32873191	P31L	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
8	32873191	P31N	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
9	32873191	P31Q	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
10	32873191	P31R	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
11	32873191	P31S	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
12	32873191	P31T	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
13	32873191	V16D	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View
14	32873191	W45A	Rev	Rev	Acquired Immunodeficiency Syndrome	D G T	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE148796	scRNA-seq	4	Illumina NextSeq 500 (Homo sapiens)
E   GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE246082 - MX2 expression across samples

Volcano Plot

Bar Plot