HIV Target gene Detail Information

> PRKCH Gene Search Result


Gene Information
Gene Name PRKCH
Gene ID 5583
Gene Full Name protein kinase C eta
Gene Alias PKC-L|PKCL|PRKCL|nPKC-eta|uORF2
Transcripts ENSG00000027075
Virus HIV
Gene Type protein-coding
HPA Location Info Cytosol;Plasma membrane;
Membrane Info Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID P24723
HGNC ID HGNC:9403
OMIM ID 605437
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]
Target gene [PRKCH] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000369 chr14 262 102 147 511 View
4002154 chr14 101 3 5 109 View
4006817 chr14 20 1 1 22 View
4006972 chr14 3 16 2 21 View
4007318 chr14 4 13 3 20 View
4007381 chr14 2 15 2 19 View
4009013 chr14 5 8 0 13 View
4009713 chr14 6 3 2 11 View
4010558 chr14 4 3 1 8 View
4014141 chr14 1 1 0 2 View

Target gene [PRKCH] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE221688 		Chip-seq;scATAC-Seq;scRNA-Seq 12 Illumina NovaSeq 6000 (Homo sapiens)
GSE99737 RNA-seq 9 Illumina HiSeq 2500 (Homo sapiens)
GSE144332 RNA-seq 75 NextSeq 550 (Homo sapiens)
S
  GSE157829 		scRNA-seq 7 Illumina HiSeq 2500 (Homo sapiens)
C
  GSE165705 		Chip-seq 30 Illumina NovaSeq 6000 (Homo sapiens)
GSE164264 RNA-seq 6 BGISEQ-500 (Homo sapiens)
GSE262621 RNA-seq 70 Illumina NovaSeq 6000 (Homo sapiens)
GSE202410 scRNA-seq 24 Illumina HiSeq 4000 (Homo sapiens)
GSE128121 RNA-seq 16 Illumina HiSeq 4000 (Homo sapiens)
E
  GSE162914 		RNA-seq 211 Illumina HiSeq 2500 (Homo sapiens)
GSE187515 scRNA-seq 104 Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982 Methylation profiling (Array) 576 Infinium MethylationEPIC
C
  GSE144329 		ATAC-seq 96 NextSeq 550 (Homo sapiens)
GSE205204 RNA-seq 14 Illumina NovaSeq 6000 (Homo sapiens)
GSE125686 RNA-seq 62 Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
S
  GSE198339 		scRNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
S
  GSE233747 		scRNA-seq 40 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE220859 		Chip-seq 11 Illumina NovaSeq 6000 (Homo sapiens)
GSE165708 RNA-seq 100 Illumina HiSeq 4000 (Homo sapiens)
C
  GSE211651 		Chip-seq;RNA-seq;PRO-seq 39 Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE198809 scRNA-seq 46 Illumina NovaSeq 6000 (Homo sapiens)
GSE68028 MeDIP-chip 1 NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C
  GSE100376 		ATAC-seq 24 Illumina NextSeq 500 (Homo sapiens)
GSE167211 RNA-seq 1 Illumina HiSeq 2000 (Homo sapiens)
GSE165132 RNA-seq 56 NextSeq 550 (Homo sapiens)
S
  GSE228078 		scRNA-seq 12 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE100266 		ATAC-seq;Chip-seq;RNA-seq 32 Illumina HiSeq 2500 (Homo sapiens)
C
  GSE165703 		ATAC-seq 82 Illumina HiSeq 4000 (Homo sapiens)
S
  GSE148796 		scRNA-seq 4 Illumina NextSeq 500 (Homo sapiens)
GSE246082 RNA-seq 6 Illumina HiSeq 4000 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE162914 - PRKCH expression across samples

Volcano Plot

Bar Plot