Gene Name	TNRC6B
Gene ID	23112
Gene Full Name	trinucleotide repeat containing adaptor 6B
Gene Alias	GDSBA
Transcripts	ENSG00000100354
Virus	HIV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Disease related genes, Metabolic proteins, Predicted intracellular proteins
Uniport_ID	Q9UPQ9
HGNC ID	HGNC:29190
OMIM ID	610740
Summary	Enables RNA binding activity. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; and regulatory ncRNA-mediated gene silencing. Acts upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Apr 2025]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000622	chr22	209	107	24	340	View
4000930	chr22	218	10	18	246	View
4000980	chr22	212	17	5	234	View
4001129	chr22	39	91	78	208	View
4001367	chr22	137	19	16	172	View
4001730	chr22	129	6	1	136	View
4001781	chr22	101	15	16	132	View
4002080	chr22	113	1	0	114	View
4002148	chr22	44	1	67	112	View
4002221	chr22	100	5	0	105	View
4002456	chr22	42	1	53	96	View
4003456	chr22	41	15	5	61	View
4004060	chr22	47	3	0	50	View
4005438	chr22	15	12	5	32	View
4005757	chr22	12	7	11	30	View
4005917	chr22	22	6	0	28	View
4006573	chr22	12	11	1	24	View
4006755	chr22	6	17	0	23	View
4007621	chr22	9	5	4	18	View
4008777	chr22	11	2	1	14	View
4009033	chr22	6	7	0	13	View
4009391	chr22	3	8	1	12	View
4009692	chr22	7	4	0	11	View
4010592	chr22	5	3	0	8	View
4010971	chr22	3	5	0	8	View
4011747	chr22	4	2	0	6	View
4011914	chr22	6	0	0	6	View
4012159	chr22	3	2	0	5	View
4012602	chr22	3	2	0	5	View
4012974	chr22	2	2	0	4	View
4013200	chr22	3	1	0	4	View
4014449	chr22	1	1	0	2	View
4014450	chr22	0	2	0	2	View
4016009	chr22	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE148796	scRNA-seq	4	Illumina NextSeq 500 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - TNRC6B peak across samples

Peak Plot

> Dataset: GSE165705 - TNRC6B peak across samples

Peak Plot

> Dataset: GSE30738 - TNRC6B peak across samples

Peak Plot

> Dataset: GSE144329 - TNRC6B peak across samples

Peak Plot

> Dataset: GSE220859 - TNRC6B peak across samples

Peak Plot

> Dataset: GSE211651 - TNRC6B peak across samples

Peak Plot

> Dataset: GSE100376 - TNRC6B peak across samples

Peak Plot

> Dataset: GSE100266 - TNRC6B peak across samples

Peak Plot

> Dataset: GSE165703 - TNRC6B peak across samples

Peak Plot