Gene Name	UBE2D2
Gene ID	7322
Gene Full Name	ubiquitin conjugating enzyme E2 D2
Gene Alias	E2(17)KB2|PUBC1|UBC4|UBC4/5|UBCH4|UBCH5B
Transcripts	ENSG00000131508
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Plasma membrane, Cytosol;
Membrane Info	Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	P62837
HGNC ID	HGNC:12475
OMIM ID	602962
Summary	Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002311	chr5	10	32	58	100	View
4003395	chr5	10	25	27	62	View
4004471	chr5	7	14	23	44	View
4004614	chr5	7	14	21	42	View
4004757	chr5	7	12	21	40	View
4004758	chr5	7	12	21	40	View
4004759	chr5	7	12	21	40	View
4004760	chr5	7	12	21	40	View
4004761	chr5	7	12	21	40	View
4004762	chr5	7	12	21	40	View
4004845	chr5	7	11	21	39	View
4004846	chr5	7	11	21	39	View
4004847	chr5	7	11	21	39	View
4004848	chr5	7	11	21	39	View
4005019	chr5	7	11	19	37	View
4007760	chr5	14	0	4	18	View
4008973	chr5	13	0	0	13	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE198809	scRNA-seq	46	Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE148796	scRNA-seq	4	Illumina NextSeq 500 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - UBE2D2 peak across samples

Peak Plot

> Dataset: GSE165705 - UBE2D2 peak across samples

Peak Plot

> Dataset: GSE144329 - UBE2D2 peak across samples

Peak Plot

> Dataset: GSE220859 - UBE2D2 peak across samples

Peak Plot

> Dataset: GSE211651 - UBE2D2 peak across samples

Peak Plot

> Dataset: GSE100376 - UBE2D2 peak across samples

Peak Plot

> Dataset: GSE100266 - UBE2D2 peak across samples

Peak Plot

> Dataset: GSE165703 - UBE2D2 peak across samples

Peak Plot