Gene Name	CYTH1
Gene ID	9267
Gene Full Name	cytohesin 1
Gene Alias	B2-1|CYTOHESIN-1|D17S811E|PSCD1|SEC7
Transcripts	ENSG00000108669
Virus	HIV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q15438
HGNC ID	HGNC:9501
OMIM ID	182115
Summary	The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000398	chr17	110	265	117	492	View
4001662	chr17	85	34	25	144	View
4001758	chr17	130	3	1	134	View
4002127	chr17	64	22	25	111	View
4002136	chr17	2	46	62	110	View
4003279	chr17	48	15	2	65	View
4003621	chr17	55	2	0	57	View
4004520	chr17	42	1	0	43	View
4005359	chr17	2	16	15	33	View
4005608	chr17	22	8	1	31	View
4005754	chr17	10	16	4	30	View
4006287	chr17	17	9	0	26	View
4006996	chr17	19	1	1	21	View
4007946	chr17	16	1	0	17	View
4007973	chr17	12	5	0	17	View
4008417	chr17	4	11	0	15	View
4008418	chr17	10	3	2	15	View
4008537	chr17	9	2	4	15	View
4008642	chr17	12	2	0	14	View
4009077	chr17	3	9	1	13	View
4010848	chr17	2	5	1	8	View
4011067	chr17	4	3	0	7	View
4011593	chr17	2	4	0	6	View
4012084	chr17	3	1	1	5	View
4012924	chr17	3	1	0	4	View
4013452	chr17	2	1	0	3	View
4014169	chr17	2	0	0	2	View
4014715	chr17	0	2	0	2	View
4016800	chr17	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE198809	scRNA-seq	46	Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE148796	scRNA-seq	4	Illumina NextSeq 500 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - CYTH1 peak across samples

Peak Plot

> Dataset: GSE165705 - CYTH1 peak across samples

Peak Plot

> Dataset: GSE30738 - CYTH1 peak across samples

Peak Plot

> Dataset: GSE144329 - CYTH1 peak across samples

Peak Plot

> Dataset: GSE220859 - CYTH1 peak across samples

Peak Plot

> Dataset: GSE211651 - CYTH1 peak across samples

Peak Plot

> Dataset: GSE100376 - CYTH1 peak across samples

Peak Plot

> Dataset: GSE100266 - CYTH1 peak across samples

Peak Plot

> Dataset: GSE165703 - CYTH1 peak across samples

Peak Plot