Gene Name	GRB2
Gene ID	2885
Gene Full Name	growth factor receptor bound protein 2
Gene Alias	ASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2
Transcripts	ENSG00000177885
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Cytosol;Primary cilium, Centrosome;
Membrane Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	P62993
HGNC ID	HGNC:4566
OMIM ID	108355
Summary	The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000412	chr17	82	282	120	484	View
4000480	chr17	89	262	83	434	View
4002543	chr17	89	0	1	90	View
4002871	chr17	73	3	1	77	View
4003422	chr17	61	1	0	62	View
4003669	chr17	35	16	5	56	View
4003679	chr17	55	1	0	56	View
4005883	chr17	20	9	0	29	View
4006030	chr17	13	14	0	27	View
4006337	chr17	24	1	0	25	View
4006567	chr17	6	6	12	24	View
4007751	chr17	4	14	0	18	View
4008945	chr17	1	8	4	13	View
4009937	chr17	7	3	0	10	View
4012922	chr17	3	1	0	4	View
4014165	chr17	2	0	0	2	View
4014166	chr17	2	0	0	2	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE198809	scRNA-seq	46	Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE148796	scRNA-seq	4	Illumina NextSeq 500 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE221688 - GRB2 peak across samples

Peak Plot

> Dataset: GSE165705 - GRB2 peak across samples

Peak Plot

> Dataset: GSE30738 - GRB2 peak across samples

Peak Plot

> Dataset: GSE144329 - GRB2 peak across samples

Peak Plot

> Dataset: GSE220859 - GRB2 peak across samples

Peak Plot

> Dataset: GSE211651 - GRB2 peak across samples

Peak Plot

> Dataset: GSE100376 - GRB2 peak across samples

Peak Plot

> Dataset: GSE100266 - GRB2 peak across samples

Peak Plot

> Dataset: GSE165703 - GRB2 peak across samples

Peak Plot