Gene Name	NFKB1
Gene ID	4790
Gene Full Name	nuclear factor kappa B subunit 1
Gene Alias	CVID12|EBP-1|KBF1|NF-kB|NF-kB1|NF-kappa-B1|NF-kappaB|NF-kappabeta|NFKB-p105|NFKB-p50|NFkappaB
Transcripts	ENSG00000109320
Virus	HIV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors
Uniport_ID	P19838
HGNC ID	HGNC:7794
OMIM ID	164011
Summary	This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	24465210	A14L	Vpu	Vpu	HIV Infections	G R I C L T	View
2	24465210	A15T	Vpu	Vpu	HIV Infections	G R I C L T	View
3	24465210	A15V	Vpu	Vpu	HIV Infections	G R I C L T	View
4	24465210	A19E	Vpu	Vpu	HIV Infections	G R I C L T	View
5	24465210	A50T	Vpu	Vpu	HIV Infections	G R I C L T	View
6	24465210	A50V	Vpu	Vpu	HIV Infections	G R I C L T	View
7	24465210	D52V	Vpu	Vpu	HIV Infections	G R I C L T	View
8	24465210	E29K	Vpu	Vpu	HIV Infections	G R I C L T	View
9	24465210	E56G	Vpu	Vpu	HIV Infections	G R I C L T	View
10	24465210	E58K	Vpu	Vpu	HIV Infections	G R I C L T	View
11	24465210	E62G	Vpu	Vpu	HIV Infections	G R I C L T	View
12	24465210	G59R	Vpu	Vpu	HIV Infections	G R I C L T	View
13	24465210	I16E	Vpu	Vpu	HIV Infections	G R I C L T	View
14	24465210	I17T	Vpu	Vpu	HIV Infections	G R I C L T	View
15	24465210	I39L	Vpu	Vpu	HIV Infections	G R I C L T	View
16	24465210	I9M	Vpu	Vpu	HIV Infections	G R I C L T	View
17	24465210	N55H	Vpu	Vpu	HIV Infections	G R I C L T	View
18	24465210	S53N	Vpu	Vpu	HIV Infections	G R I C L T	View
19	24465210	V22A	Vpu	Vpu	HIV Infections	G R I C L T	View

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003015	chr4	48	22	2	72	View
4004783	chr4	10	4	25	39	View
4013703	chr4	3	0	0	3	View
4015123	chr4	1	0	0	1	View
4015183	chr4	0	1	0	1	View
4016768	chr4	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE99737	RNA-seq	9	Illumina HiSeq 2500 (Homo sapiens)
GSE144332	RNA-seq	75	NextSeq 550 (Homo sapiens)
GSE157829	scRNA-seq	7	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)
C   GSE30738	Chip-seq	2	Illumina Genome Analyzer II (Homo sapiens)
GSE262621	RNA-seq	70	Illumina NovaSeq 6000 (Homo sapiens)
GSE202410	scRNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
S   GSE187515	scRNA-seq	104	Illumina MiSeq (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE198339	scRNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE233747	scRNA-seq	40	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE165708	RNA-seq	100	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
S   GSE198809	scRNA-seq	46	Illumina NovaSeq 6000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE228078	scRNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE148796	scRNA-seq	4	Illumina NextSeq 500 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)

• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.

> Dataset: GSE187515 - Gene expression in cell subsets
> Dataset: GSE198809 - Gene expression in cell subsets